ELANE - Neutrophil elastase - human protein (Function)
 
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ELANE »  Neutrophil elastase   [ EC 3.4.21.37 ]
 
Protein also known as:  Bone marrow serine protease.
Gene name:  ELANE
Family name: Peptidase S1 » Elastase
Entry whose protein(s) existence is based on evidence at protein level
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1 169 1
GENE REF ISO

Function

 show evidences
Overview 
Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.  
1
  • CuratedUniProtKB
GO molecular function 
Cytokine bindingdefinition[GO:0019955]  
1
  • IPIUniProtKB
Endopeptidase activitydefinition[GO:0004175]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Heparin bindingdefinition[GO:0008201]  
1
  • IDAMGI
Peptidase activitydefinition[GO:0008233]  
1
  • IDAMGI
Protease bindingdefinition[GO:0002020]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
  • IEAOrtholog Compara
GO biological process 
Acute inflammatory response to antigenic stimulusdefinition[GO:0002438] silver  
  • IEAOrtholog Compara
Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • NASUniProtKB
Defense response to bacteriumdefinition[GO:0042742]  
1
  • IDAUniProtKB
Leukocyte migrationdefinition[GO:0050900] silver  
  • IEAOrtholog Compara
Negative regulation of chemokine biosynthetic processdefinition[GO:0045079]  
1
  • IDAUniProtKB
Negative regulation of chemotaxisdefinition[GO:0050922]  
1
  • NASUniProtKB
Negative regulation of growth of symbiont in hostdefinition[GO:0044130] silver  
  • IEAOrtholog Compara
Negative regulation of inflammatory responsedefinition[GO:0050728]  
1
  • NASUniProtKB
Negative regulation of interleukin-8 biosynthetic processdefinition[GO:0045415]  
1
  • IDAUniProtKB
Neutrophil mediated killing of fungusdefinition[GO:0070947] silver  
  • IEAOrtholog Compara
Phagocytosisdefinition[GO:0006909] silver  
  • IEAOrtholog Compara
Positive regulation of immune responsedefinition[GO:0050778] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-8 biosynthetic processdefinition[GO:0045416]  
1
  • IDAUniProtKB
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
1
  • NASUniProtKB
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
1
  • IDAUniProtKB
Protein catabolic processdefinition[GO:0030163]  
1
  • NASUniProtKB
Proteolysisdefinition[GO:0006508]  
1
  • IDAMGI
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to UVdefinition[GO:0009411]  
1
  • IDAUniProtKB
Response to yeastdefinition[GO:0001878] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.37: Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Systemic lupus erythematosus  hsa05322+1991  
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_133391  
Extracellular matrix organization  REACT_118779  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P08246
Other
GeneWiki: Neutrophil_elastase
GenomeRNAi: 1991
PRO: PR:P08246
Chemistry
GuidetoPHARMACOLOGY: 2358