MMP3 - Stromelysin-1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
MMP3 »  Stromelysin-1   [ EC 3.4.24.17 ]  (SL-1)
 
Protein also known as:  Matrix metalloproteinase-3 (MMP-3).
Gene name:  MMP3
Family name: Peptidase M10A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 343 1
GENE REF ISO

Function

 show evidences
Overview 
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Endopeptidase activitydefinition[GO:0004175]  
1
  • IDAParkinsonsUK-UCL
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Cellular response to amino acid stimulusdefinition[GO:0071230] silver  
  • IEAOrtholog Compara
Negative regulation of hydrogen peroxide metabolic processdefinition[GO:0010727]  
1
  • IDAParkinsonsUK-UCL
Proteolysisdefinition[GO:0006508]  
1
  • IDAParkinsonsUK-UCL
Regulation of cell migrationdefinition[GO:0030334] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.17: Preferential cleavage where P1', P2' and P3' are hydrophobic residues.  
  • CuratedUniProtKB
It requires the following cofactors
Binds 4 calcium ions per subunit.  
  • CuratedUniProtKB
Binds 2 zinc ions per subunit.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Rheumatoid arthritis  hsa05323+4314  
According to Reactome, this protein belongs to the following pathways:
Activation of Matrix Metalloproteinases  REACT_118682  
Assembly of collagen fibrils and other multimeric structures  REACT_150180  
Collagen degradation  REACT_150401  
Collagen degradation  REACT_222620  
Degradation of the extracellular matrix  REACT_118572  
EGFR Transactivation by Gastrin  REACT_121096  
 

Keywords

Biological process 
Collagen degradation  definition   [KW-0177]
Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MMP3
GenomeRNAi: 4314
PRO: PR:P08254
Chemistry
GuidetoPHARMACOLOGY: 1630