CTSG - Cathepsin G - human protein (Function)
 
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Protein
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CTSG »  Cathepsin G   [ EC 3.4.21.20 ]  (CG)
 
Gene name:  CTSG
Family name: Peptidase S1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.  
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  • CuratedUniProtKB
GO molecular function 
Heparin bindingdefinition[GO:0008201]  
1
  • IDAMGI
Peptidase activitydefinition[GO:0008233]  
1
  • IDAMGI
Serine-type endopeptidase activitydefinition[GO:0004252]  
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  • IDAUniProtKB
GO biological process 
Defense response to fungusdefinition[GO:0050832] silver  
  • IBARefGenome
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Negative regulation of growth of symbiont in hostdefinition[GO:0044130] silver  
  • IEAOrtholog Compara
Neutrophil mediated killing of gram-positive bacteriumdefinition[GO:0070946] silver  
  • IBARefGenome
Positive regulation of immune responsedefinition[GO:0050778] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
2
  • IDAMGI
  • IDAUniProtKB
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.20: Specificity similar to chymotrypsin C.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by soybean trypsin inhibitor, benzamidine, the synthetic peptide R13K, Z-Gly-Leu-Phe-CH2Cl, phenylmethylsulfonyl fluoride, 3,4-dichloroisocoumarin, DFP, SBTI and alpha-1-antitrypsin. Inhibited by LPS from P.aeruginosa but not by LPS from S.minnesota. Not inhibited by elastinal, CMK, TLCK and ETDA.  
3
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+1511  
Lysosome  hsa04142+1511  
Neuroactive ligand-receptor interaction  hsa04080+1511  
Renin-angiotensin system  hsa04614+1511  
Systemic lupus erythematosus  hsa05322+1511  
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_118779  
Metabolism of proteins  REACT_17015  
 

Biophysicochemical properties

Kinetic parameters
KM 0.26 mM for Suc-Ala-Ala-Pro-Phe-SBzl
KM 1.15 mM for Z-Lys-SBzl

Keywords

Molecular function 
Antibiotic  definition   [KW-0044]
Antimicrobial  definition   [KW-0929]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P08311
Other
GeneWiki: Cathepsin_G
GenomeRNAi: 1511
PRO: PR:P08311
Chemistry
GuidetoPHARMACOLOGY: 2348