ADH4 - Alcohol dehydrogenase 4 - human protein (Function)
 
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Protein
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ADH4 »  Alcohol dehydrogenase 4   [ EC 1.1.1.1 ]
 
Protein also known as:  Alcohol dehydrogenase class II pi chain.
Gene name:  ADH4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 39 2
GENE REF ISO

Function

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GO molecular function 
Alcohol dehydrogenase (NAD) activitydefinition[GO:0004022]  
2
  • IDAUniProtKB
Alcohol dehydrogenase activity, zinc-dependentdefinition[GO:0004024]  
1
  • IDAUniProtKB
Alditol:NADP+ 1-oxidoreductase activitydefinition[GO:0004032] silver  
  • IEAOrtholog Compara
All-trans retinal bindingdefinition[GO:0005503]  
1
  • IDAUniProtKB
Benzaldehyde dehydrogenase activitydefinition[GO:0019115]  
1
  • IDAUniProtKB
NAD bindingdefinition[GO:0051287]  
1
  • IDAUniProtKB
NADPH:quinone reductase activitydefinition[GO:0003960]  
  • ISSOrtholog Curator
Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptordefinition[GO:0016620]  
1
  • IDAUniProtKB
Retinol bindingdefinition[GO:0019841]  
1
  • IDAUniProtKB
Retinol dehydrogenase activitydefinition[GO:0004745]  
2
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • IDAUniProtKB
GO biological process 
Alcohol catabolic processdefinition[GO:0046164]  
  • ISSOrtholog Curator
Alcohol metabolic processdefinition[GO:0006066]  
1
  • IDAUniProtKB
Cellular aldehyde metabolic processdefinition[GO:0006081]  
1
  • IDAUniProtKB
Ethanol oxidationdefinition[GO:0006069]  
1
  • IDAUniProtKB
Quinone metabolic processdefinition[GO:1901661]  
  • ISSOrtholog Curator
Retinoid metabolic processdefinition[GO:0001523]  
1
  • IDAUniProtKB
Retinol metabolic processdefinition[GO:0042572]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.1: An alcohol + NAD(+) an aldehyde or ketone + NADH.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 zinc ions per subunit.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Drug metabolism - cytochrome P450  hsa00982+127  
Fatty acid metabolism  hsa00071+127  
Glycolysis / Gluconeogenesis  hsa00010+127  
Metabolic pathways  hsa01100+127  
Metabolism of xenobiotics by cytochrome P450  hsa00980+127  
Retinol metabolism  hsa00830+127  
Tyrosine metabolism  hsa00350+127  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
Note 
There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P08319
Other
GeneWiki: ADH4
GenomeRNAi: 127
PRO: PR:P08319