INHBA - Inhibin beta A chain - human protein (Function)
 
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Gene
References

 
INHBA »  Inhibin beta A chain
 
Protein also known as:  Erythroid differentiation protein (EDF).
Gene name:  INHBA
Family name: TGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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1 192 1
GENE REF ISO

Function

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Overview 
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.  
1
  • UniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
1
  • HGNC
Growth factor activitydefinition[GO:0008083]  
1
  • UniProtKB
Hormone activitydefinition[GO:0005179]  
1
  • UniProtKB
Identical protein bindingdefinition[GO:0042802]  
1
  • UniProtKB
Peptide hormone bindingdefinition[GO:0017046]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Transforming growth factor beta receptor bindingdefinition[GO:0005160]  
1
  • RefGenome
Type II activin receptor bindingdefinition[GO:0070699]  
1
  • BHF-UCL
GO biological process 
Activin receptor signaling pathwaydefinition[GO:0032924]  
1
  • BHF-UCL
Cell cycle arrestdefinition[GO:0007050]  
1
  • HGNC
Cell developmentdefinition[GO:0048468]  
1
  • RefGenome
Cell differentiationdefinition[GO:0030154]  
1
  • UniProtKB
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • UniProtKB
Cell-cell signalingdefinition[GO:0007267]  
1
  • UniProtKB
Cellular response to cholesteroldefinition[GO:0071397] silver  
1
  • Ortholog Compara
Cellular response to follicle-stimulating hormone stimulusdefinition[GO:0071372] silver  
1
  • Ortholog Compara
Defense responsedefinition[GO:0006952]  
1
  • UniProtKB
Endodermal cell differentiationdefinition[GO:0035987]  
1
  • BHF-UCL
Erythrocyte differentiationdefinition[GO:0030218]  
1
  • UniProtKB
Extrinsic apoptotic signaling pathwaydefinition[GO:0097191]  
1
  • BHF-UCL
Eyelid development in camera-type eyedefinition[GO:0061029]  
1
  • Ortholog Curator
G1/S transition of mitotic cell cycledefinition[GO:0000082]  
1
  • HGNC
Growthdefinition[GO:0040007] silver  
1
  • InterPro 2 GO
Hair follicle developmentdefinition[GO:0001942]  
1
  • UniProtKB
Hematopoietic progenitor cell differentiationdefinition[GO:0002244]  
1
  • UniProtKB
Hemoglobin biosynthetic processdefinition[GO:0042541]  
1
  • UniProtKB
Male gonad developmentdefinition[GO:0008584]  
1
  • UniProtKB
Mesodermal cell differentiationdefinition[GO:0048333] silver  
1
  • Ortholog Compara
Negative regulation of B cell differentiationdefinition[GO:0045578]  
1
  • UniProtKB
Negative regulation of cell cycledefinition[GO:0045786]  
1
  • HGNC
Negative regulation of cell growthdefinition[GO:0030308]  
2
  • UniProtKB
  • HGNC
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • UniProtKB
Negative regulation of follicle-stimulating hormone secretiondefinition[GO:0046882]  
1
  • UniProtKB
Negative regulation of interferon-gamma biosynthetic processdefinition[GO:0045077]  
1
  • UniProtKB
Negative regulation of macrophage differentiationdefinition[GO:0045650]  
1
  • UniProtKB
Negative regulation of phosphorylationdefinition[GO:0042326]  
1
  • UniProtKB
Nervous system developmentdefinition[GO:0007399]  
1
  • UniProtKB
Odontogenesisdefinition[GO:0042476]  
1
  • UniProtKB
Ovarian follicle developmentdefinition[GO:0001541]  
2
  • UniProtKB
Palate developmentdefinition[GO:0060021]  
1
  • UniProtKB
Positive regulation of cellular protein metabolic processdefinition[GO:0032270]  
1
  • BHF-UCL
Positive regulation of erythrocyte differentiationdefinition[GO:0045648]  
1
  • HGNC
Positive regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001241]  
1
  • UniProtKB
Positive regulation of follicle-stimulating hormone secretiondefinition[GO:0046881]  
1
  • UniProtKB
Positive regulation of ovulationdefinition[GO:0060279]  
1
  • Ortholog Curator
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
1
  • BHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • UniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Progesterone secretiondefinition[GO:0042701]  
1
  • UniProtKB
Regulation of follicle-stimulating hormone secretiondefinition[GO:0046880]  
1
  • UniProtKB
Regulation of MAPK cascadedefinition[GO:0043408]  
1
  • RefGenome
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • UniProtKB
Response to drugdefinition[GO:0042493]  
1
  • UniProtKB
SMAD protein signal transductiondefinition[GO:0060395]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+3624  
TGF-beta signaling pathway  hsa04350+3624  
According to Reactome, this protein belongs to the following pathways:
Antagonism of Activin by Follistatin  REACT_150276  
Glycoprotein hormones  REACT_15398  
Signaling by Activin  REACT_150238  
 

Keywords

Molecular function 
Growth factor  definition   [KW-0339]
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 3624
PRO: PR:P08476