INHBA - Inhibin beta A chain - human protein (Function)
 
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INHBA »  Inhibin beta A chain
 
Protein also known as:  Erythroid differentiation protein (EDF).
Gene name:  INHBA
Family name: TGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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1 172 1
GENE REF ISO

Function

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Overview 
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.  
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
1
  • IDAHGNC
Growth factor activitydefinition[GO:0008083]  
1
  • TASUniProtKB
Hormone activitydefinition[GO:0005179]  
1
  • TASUniProtKB
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIUniProtKB
Peptide hormone bindingdefinition[GO:0017046]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Type II activin receptor bindingdefinition[GO:0070699]  
1
  • IPIBHF-UCL
GO biological process 
Activin receptor signaling pathwaydefinition[GO:0032924]  
1
  • IDABHF-UCL
Cell cycle arrestdefinition[GO:0007050]  
1
  • IDAHGNC
Cell differentiationdefinition[GO:0030154]  
1
  • TASUniProtKB
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASUniProtKB
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASUniProtKB
Cellular response to cholesteroldefinition[GO:0071397] silver  
  • IEAOrtholog Compara
Cellular response to follicle-stimulating hormone stimulusdefinition[GO:0071372] silver  
  • IEAOrtholog Compara
Defense responsedefinition[GO:0006952]  
1
  • TASUniProtKB
Erythrocyte differentiationdefinition[GO:0030218]  
1
  • NASUniProtKB
Extrinsic apoptotic signaling pathwaydefinition[GO:0097191]  
1
  • IDABHF-UCL
Eyelid development in camera-type eyedefinition[GO:0061029]  
  • ISSOrtholog Curator
G1/S transition of mitotic cell cycledefinition[GO:0000082]  
1
  • IDAHGNC
Growthdefinition[GO:0040007] silver  
  • IEAInterPro 2 GO
Hair follicle developmentdefinition[GO:0001942]  
1
  • IGIUniProtKB
Hematopoietic progenitor cell differentiationdefinition[GO:0002244]  
1
  • IDAUniProtKB
Hemoglobin biosynthetic processdefinition[GO:0042541]  
1
  • IDAUniProtKB
Male gonad developmentdefinition[GO:0008584]  
1
  • IGIUniProtKB
Mesodermal cell differentiationdefinition[GO:0048333] silver  
  • IEAOrtholog Compara
Negative regulation of B cell differentiationdefinition[GO:0045578]  
1
  • TASUniProtKB
Negative regulation of cell cycledefinition[GO:0045786]  
1
  • IDAHGNC
Negative regulation of cell growthdefinition[GO:0030308]  
2
  • IDAUniProtKB
  • IDAHGNC
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IDAUniProtKB
Negative regulation of follicle-stimulating hormone secretiondefinition[GO:0046882]  
1
  • NASUniProtKB
Negative regulation of interferon-gamma biosynthetic processdefinition[GO:0045077]  
1
  • TASUniProtKB
Negative regulation of macrophage differentiationdefinition[GO:0045650]  
1
  • TASUniProtKB
Negative regulation of phosphorylationdefinition[GO:0042326]  
1
  • TASUniProtKB
Nervous system developmentdefinition[GO:0007399]  
1
  • NASUniProtKB
Odontogenesisdefinition[GO:0042476]  
1
  • IGIUniProtKB
Ovarian follicle developmentdefinition[GO:0001541]  
2
  • IGIUniProtKB
Palate developmentdefinition[GO:0060021]  
1
  • IGIUniProtKB
Positive regulation of erythrocyte differentiationdefinition[GO:0045648]  
1
  • IDAHGNC
Positive regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001241]  
1
  • IDAUniProtKB
Positive regulation of follicle-stimulating hormone secretiondefinition[GO:0046881]  
1
  • TASUniProtKB
Positive regulation of ovulationdefinition[GO:0060279]  
  • ISSOrtholog Curator
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Progesterone secretiondefinition[GO:0042701]  
1
  • IGIUniProtKB
Regulation of follicle-stimulating hormone secretiondefinition[GO:0046880]  
1
  • IGIUniProtKB
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • IDAUniProtKB
Response to drugdefinition[GO:0042493]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+3624  
TGF-beta signaling pathway  hsa04350+3624  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Growth factor  definition   [KW-0339]
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 3624
PRO: PR:P08476