ITGA2B - Integrin alpha-IIb - human protein (Function)
 
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ITGA2B »  Integrin alpha-IIb
 
Protein also known as:  Platelet membrane glycoprotein IIb; CD antigen CD41. Cleaved into:  Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2.
Gene name:  ITGA2B
Family name: Integrin alpha chain
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 279 3
GENE REF ISO

Function

 show evidences
Overview 
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.  
  • CuratedUniProtKB
GO molecular function 
Extracellular matrix bindingdefinition[GO:0050840] silver  
  • IEAOrtholog Compara
Fibrinogen bindingdefinition[GO:0070051] silver  
  • IEAOrtholog Compara
Identical protein bindingdefinition[GO:0042802]  
3
  • IPIIntAct
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
GO biological process 
Cell adhesiondefinition[GO:0007155]  
2
  • TASPINC
Cell-matrix adhesiondefinition[GO:0007160] silver  
  • IEAOrtholog Compara
Integrin-mediated signaling pathwaydefinition[GO:0007229]  
  • IEAUniProtKB KW
Platelet aggregationdefinition[GO:0070527] silver  
  • IEAOrtholog Compara
Positive regulation of leukocyte migrationdefinition[GO:0002687] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+3674  
Dilated cardiomyopathy  hsa05414+3674  
ECM-receptor interaction  hsa04512+3674  
Focal adhesion  hsa04510+3674  
Hematopoietic cell lineage  hsa04640+3674  
Hypertrophic cardiomyopathy (HCM)  hsa05410+3674  
Pathways in cancer  hsa05200+3674  
Regulation of actin cytoskeleton  hsa04810+3674  
Small cell lung cancer  hsa05222+3674  
According to Reactome, this protein belongs to the following pathways:
ECM proteoglycans  REACT_163906  
Integrin alphaIIb beta3 signaling  REACT_15523  
Integrin cell surface interactions  REACT_13552  
p130Cas linkage to MAPK signaling for integrins  REACT_15381  
Signal transduction by L1  REACT_22272  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Molecular function 
Integrin  definition   [KW-0401]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ITGA2B
GenomeRNAi: 3674
PRO: PR:P08514