LPA - Apolipoprotein(a) - human protein (Function)
 
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LPA »  Apolipoprotein(a)   [ EC 3.4.21.- ]  (Lp(a))
 
Gene name:  LPA
Family name: Peptidase S1 » Plasminogen
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.  
2
  • UniProtKB
GO molecular function 
Apolipoprotein bindingdefinition[GO:0034185]  
1
  • BHF-UCL
Endopeptidase inhibitor activitydefinition[GO:0004866]  
1
  • PINC
Fibronectin bindingdefinition[GO:0001968]  
1
  • BHF-UCL
Heparin bindingdefinition[GO:0008201]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Serine-type endopeptidase activitydefinition[GO:0004252]  
1
  • BHF-UCL
GO biological process 
Blood circulationdefinition[GO:0008015]  
1
  • PINC
Labyrinthine layer blood vessel developmentdefinition[GO:0060716] silver  
1
  • Ortholog Compara
Lipid metabolic processdefinition[GO:0006629]  
1
  • PINC
Lipid transportdefinition[GO:0006869]  
1
  • UniProtKB KW
Mononuclear cell migrationdefinition[GO:0071674] silver  
1
  • Ortholog Compara
Muscle cell cellular homeostasisdefinition[GO:0046716] silver  
1
  • Ortholog Compara
Myoblast differentiationdefinition[GO:0045445] silver  
1
  • Ortholog Compara
Negative regulation of endopeptidase activitydefinition[GO:0010951]  
1
  • GOC
Proteolysis involved in cellular protein catabolic processdefinition[GO:0051603] silver  
1
  • Ortholog Compara
Tissue regenerationdefinition[GO:0042246] silver  
1
  • Ortholog Compara
Trophoblast giant cell differentiationdefinition[GO:0060707] silver  
1
  • Ortholog Compara
Enzymatic activity 
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
LDL-mediated lipid transport  REACT_6934  
 

Keywords

Biological process 
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links