PDHA1 - Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial - human protein (Function)
 
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PDHA1 »  Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial   [ EC 1.2.4.1 ]
 
Protein also known as:  PDHE1-A type I.
Gene name:  PDHA1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 82 4
GENE REF ISO

Function

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Overview 
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.  
2
  • CuratedUniProtKB
GO molecular function 
Pyruvate dehydrogenase (acetyl-transferring) activitydefinition[GO:0004739]  
  • IEAEC 2 GO
Pyruvate dehydrogenase activitydefinition[GO:0004738]  
1
  • IDAUniProtKB
GO biological process 
Acetyl-CoA biosynthetic process from pyruvatedefinition[GO:0006086]  
1
  • IDAUniProtKB
Glucose metabolic processdefinition[GO:0006006]  
  • IEAUniProtKB KW
Glycolytic processdefinition[GO:0006096] silver  
  • IEAInterPro 2 GO
Tricarboxylic acid cycledefinition[GO:0006099]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.2.4.1: Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).  
3
  • CuratedUniProtKB
It requires the following cofactor
Thiamine pyrophosphate.  
2
  • CuratedUniProtKB
It is regulated in the following manner
Pyruvate dehydrogenase activity is inhibited by phosphorylation of PDHA1; it is reactivated by dephosphorylation.  
3
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Butanoate metabolism  hsa00650+5160  
Citrate cycle (TCA cycle)  hsa00020+5160  
Glycolysis / Gluconeogenesis  hsa00010+5160  
Metabolic pathways  hsa01100+5160  
Pyruvate metabolism  hsa00620+5160  
Valine, leucine and isoleucine biosynthesis  hsa00290+5160  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Glucose metabolism  definition   [KW-0313]
Tricarboxylic acid cycle  definition   [KW-0816]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P08559
Other
GeneWiki: Pyruvate_dehydrogenase_(lipoamide)_alpha_1
GenomeRNAi: 5160
PRO: PR:P08559