CD14 - Monocyte differentiation antigen CD14 - human protein (Function)
 
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CD14 »  Monocyte differentiation antigen CD14
 
Protein also known as:  Myeloid cell-specific leucine-rich glycoprotein; CD antigen CD14. Cleaved into:  Monocyte differentiation antigen CD14, membrane-bound form; Monocyte differentiation antigen CD14, urinary form.
Gene name:  CD14
Entry whose protein(s) existence is based on evidence at protein level
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1 384 1
GENE REF ISO

Function

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Overview 
In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.  
2
  • UniProtKB
GO molecular function 
Lipopolysaccharide bindingdefinition[GO:0001530]  
1
  • MGI
Lipoteichoic acid bindingdefinition[GO:0070891]  
1
  • MGI
Opsonin receptor activitydefinition[GO:0001847]  
1
  • BHF-UCL
Peptidoglycan receptor activitydefinition[GO:0016019]  
1
  • PINC
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • PINC
Cellular response to lipopolysaccharidedefinition[GO:0071222]  
2
  • MGI
  • UniProtKB
Cellular response to lipoteichoic aciddefinition[GO:0071223]  
1
  • MGI
Inflammatory responsedefinition[GO:0006954] silver  
1
  • Ortholog Compara
Phagocytosisdefinition[GO:0006909]  
1
  • PINC
Positive regulation of cytokine secretiondefinition[GO:0050715] silver  
1
  • Ortholog Compara
Positive regulation of endocytosisdefinition[GO:0045807] silver  
1
  • Ortholog Compara
Positive regulation of tumor necrosis factor productiondefinition[GO:0032760]  
2
  • MGI
  • UniProtKB
Positive regulation of type I interferon productiondefinition[GO:0032481] silver  
1
  • Ortholog Compara
Receptor-mediated endocytosisdefinition[GO:0006898] silver  
1
  • Ortholog Compara
Response to electrical stimulusdefinition[GO:0051602] silver  
1
  • Ortholog Compara
Response to ethanoldefinition[GO:0045471] silver  
1
  • Ortholog Compara
Response to heatdefinition[GO:0009408] silver  
1
  • Ortholog Compara
Response to magnesium iondefinition[GO:0032026] silver  
1
  • Ortholog Compara
Response to tumor necrosis factordefinition[GO:0034612] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+929  
Hematopoietic cell lineage  hsa04640+929  
Legionellosis  hsa05134+929  
MAPK signaling pathway  hsa04010+929  
Pathogenic Escherichia coli infection  hsa05130+929  
Pertussis  hsa05133+929  
Phagosome  hsa04145+929  
Regulation of actin cytoskeleton  hsa04810+929  
Salmonella infection  hsa05132+929  
Toll-like receptor signaling pathway  hsa04620+929  
Tuberculosis  hsa05152+929  
According to Reactome, this protein belongs to the following pathways:
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon  R-HSA-936964  
IKK complex recruitment mediated by RIP1  R-HSA-937041  
IRAK4 deficiency (TLR2/4)  R-HSA-5603041  
Ligand-dependent caspase activation  R-HSA-140534  
MyD88 deficiency (TLR2/4)  R-HSA-5602498  
MyD88-independent TLR3/TLR4 cascade  R-HSA-166166  
MyD88:Mal cascade initiated on plasma membrane  R-HSA-166058  
Toll Like Receptor 4 (TLR4) Cascade  R-HSA-166016  
Toll Like Receptor TLR1:TLR2 Cascade  R-HSA-168179  
Toll Like Receptor TLR6:TLR2 Cascade  R-HSA-168188  
TRAF6 mediated induction of TAK1 complex  R-HSA-937072  
Transfer of LPS from LBP carrier to CD14  R-HSA-166020  
TRIF-mediated programmed cell death  R-HSA-2562578  
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Inflammatory response  definition   [KW-0395]
Innate immunity  definition   [KW-0399]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD14
GenomeRNAi: 929
PRO: PR:P08571