MET - Hepatocyte growth factor receptor - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
MET »  Hepatocyte growth factor receptor   [ EC 2.7.10.1 ]  (HGF receptor)
 
Protein also known as:  Tyrosine-protein kinase Met.
Gene name:  MET
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 827 3
GENE REF ISO

Function

 show evidences
Overview 
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells.  
1
  • UniProtKB
Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.  
1
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Hepatocyte growth factor-activated receptor activitydefinition[GO:0005008] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
26
  • IntAct
  • UniProtKB
Protein phosphatase bindingdefinition[GO:0019903]  
1
  • UniProtKB
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • UniProtKB
GO biological process 
Activation of MAPK activitydefinition[GO:0000187] silver  
1
  • Ortholog Compara
Adult behaviordefinition[GO:0030534] silver  
1
  • Ortholog Compara
Brain developmentdefinition[GO:0007420] silver  
1
  • Ortholog Compara
Branching morphogenesis of an epithelial tubedefinition[GO:0048754]  
1
  • UniProtKB
Cell proliferationdefinition[GO:0008283]  
1
  • PINC
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • UniProtKB
Endothelial cell morphogenesisdefinition[GO:0001886]  
1
  • UniProtKB
Glucose homeostasisdefinition[GO:0042593] silver  
1
  • Ortholog Compara
Hepatocyte growth factor receptor signaling pathwaydefinition[GO:0048012] silver  
1
  • Ortholog Compara
Liver developmentdefinition[GO:0001889] silver  
1
  • Ortholog Compara
Muscle cell migrationdefinition[GO:0014812] silver  
1
  • Ortholog Compara
Myoblast proliferationdefinition[GO:0051450] silver  
1
  • Ortholog Compara
Myotube differentiationdefinition[GO:0014902] silver  
1
  • Ortholog Compara
Negative regulation of hydrogen peroxide-mediated programmed cell deathdefinition[GO:1901299]  
1
  • BHF-UCL
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
4
  • GOC
  • EC 2 GO
  • InterPro 2 GO
  • UniProtKB KW
Placenta developmentdefinition[GO:0001890] silver  
1
  • Ortholog Compara
Positive chemotaxisdefinition[GO:0050918]  
1
  • UniProtKB
Positive regulation of endothelial cell chemotaxisdefinition[GO:2001028]  
1
  • UniProtKB
Positive regulation of glucose transportdefinition[GO:0010828] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • BHF-UCL
Protein autophosphorylationdefinition[GO:0046777] silver  
1
  • Ortholog Compara
Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingdefinition[GO:0060665] silver  
1
  • Ortholog Compara
Semaphorin-plexin signaling pathwaydefinition[GO:0071526]  
1
  • UniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Skeletal muscle tissue developmentdefinition[GO:0007519] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • PROSITE-ProRule
  • UniProtKB
It is regulated in the following manner
In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+4233  
Axon guidance  hsa04360+4233  
Bacterial invasion of epithelial cells  hsa05100+4233  
Cytokine-cytokine receptor interaction  hsa04060+4233  
Endocytosis  hsa04144+4233  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+4233  
Focal adhesion  hsa04510+4233  
Malaria  hsa05144+4233  
Melanoma  hsa05218+4233  
Pathways in cancer  hsa05200+4233  
Renal cell carcinoma  hsa05211+4233  
According to Reactome, this protein belongs to the following pathway:
Sema4D mediated inhibition of cell attachment and migration  REACT_19266  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: C-Met
GenomeRNAi: 4233
PRO: PR:P08581
Chemistry
GuidetoPHARMACOLOGY: 1815