MET - Hepatocyte growth factor receptor - human protein (Function)
 
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MET »  Hepatocyte growth factor receptor   [ EC 2.7.10.1 ]  (HGF receptor)
 
Protein also known as:  Tyrosine-protein kinase Met.
Gene name:  MET
Entry whose protein(s) existence is based on evidence at protein level
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1 579 3
GENE REF ISO

Function

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Overview 
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells.  
3
  • CuratedUniProtKB
Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.  
3
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Hepatocyte growth factor-activated receptor activitydefinition[GO:0005008] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
22
  • IPIIntAct
  • IPIUniProtKB
Protein phosphatase bindingdefinition[GO:0019903]  
1
  • IPIUniProtKB
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • NASUniProtKB
GO biological process 
Activation of MAPK activitydefinition[GO:0000187] silver  
  • IEAOrtholog Compara
Adult behaviordefinition[GO:0030534] silver  
  • IEAOrtholog Compara
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Branching morphogenesis of an epithelial tubedefinition[GO:0048754]  
1
  • IMPUniProtKB
Cell proliferationdefinition[GO:0008283]  
1
  • TASPINC
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • NASUniProtKB
Glucose homeostasisdefinition[GO:0042593] silver  
  • IEAOrtholog Compara
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Muscle cell migrationdefinition[GO:0014812] silver  
  • IEAOrtholog Compara
Myoblast proliferationdefinition[GO:0051450] silver  
  • IEAOrtholog Compara
Myotube differentiationdefinition[GO:0014902] silver  
  • IEAOrtholog Compara
Negative regulation of hydrogen peroxide-mediated programmed cell deathdefinition[GO:1901299]  
1
  • IMPBHF-UCL
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
2
  • TASGOC
Placenta developmentdefinition[GO:0001890] silver  
  • IEAOrtholog Compara
Positive regulation of endothelial cell chemotaxisdefinition[GO:2001028]  
1
  • IMPUniProtKB
Positive regulation of glucose transportdefinition[GO:0010828] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDABHF-UCL
Protein autophosphorylationdefinition[GO:0046777] silver  
  • IEAOrtholog Compara
Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingdefinition[GO:0060665] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Skeletal muscle tissue developmentdefinition[GO:0007519] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
It is regulated in the following manner
In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+4233  
Axon guidance  hsa04360+4233  
Bacterial invasion of epithelial cells  hsa05100+4233  
Cytokine-cytokine receptor interaction  hsa04060+4233  
Endocytosis  hsa04144+4233  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+4233  
Focal adhesion  hsa04510+4233  
Malaria  hsa05144+4233  
Melanoma  hsa05218+4233  
Pathways in cancer  hsa05200+4233  
Renal cell carcinoma  hsa05211+4233  
According to Reactome, this protein belongs to the following pathway:
Developmental Biology  REACT_111045  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: C-Met
GenomeRNAi: 4233
PRO: PR:P08581
Chemistry
GuidetoPHARMACOLOGY: 1815