ADRB1 - Beta-1 adrenergic receptor - human protein (Function)
 
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ADRB1 »  Beta-1 adrenergic receptor
 
Protein also known as:  Beta-1 adrenoreceptor (Beta-1 adrenoceptor).
Gene name:  ADRB1
Entry whose protein(s) existence is based on evidence at protein level
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1 143 1
GENE REF ISO

Function

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Overview 
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.  
1
  • CuratedUniProtKB
GO molecular function 
Alpha-2A adrenergic receptor bindingdefinition[GO:0031694]  
1
  • IPIBHF-UCL
Beta-adrenergic receptor activitydefinition[GO:0004939]  
1
  • TASPINC
Beta1-adrenergic receptor activitydefinition[GO:0004940] silver  
  • IEAOrtholog Compara
Dopamine bindingdefinition[GO:0035240] silver  
  • IEAOrtholog Compara
Drug bindingdefinition[GO:0008144] silver  
  • IEAOrtholog Compara
Epinephrine bindingdefinition[GO:0051379] silver  
  • IEAOrtholog Compara
Norepinephrine bindingdefinition[GO:0051380] silver  
  • IEAOrtholog Compara
PDZ domain bindingdefinition[GO:0030165]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
Ras guanyl-nucleotide exchange factor activitydefinition[GO:0005088]  
1
  • IDAUniProtKB
Receptor signaling protein activitydefinition[GO:0005057]  
1
  • IDAUniProtKB
GO biological process 
Activation of adenylate cyclase activitydefinition[GO:0007190]  
1
  • TASPINC
Adenylate cyclase-activating adrenergic receptor signaling pathwaydefinition[GO:0071880]  
1
  • IDAUniProtKB
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Apoptotic processdefinition[GO:0006915] silver  
  • IEAOrtholog Compara
Brown fat cell differentiationdefinition[GO:0050873] silver  
  • IEAOrtholog Compara
Diet induced thermogenesisdefinition[GO:0002024] silver  
  • IEAOrtholog Compara
Fear responsedefinition[GO:0042596] silver  
  • IEAOrtholog Compara
Glycogen catabolic processdefinition[GO:0005980] silver  
  • IEAOrtholog Compara
Heat generationdefinition[GO:0031649] silver  
  • IEAOrtholog Compara
Lipid homeostasisdefinition[GO:0055088] silver  
  • IEAOrtholog Compara
Memorydefinition[GO:0007613] silver  
  • IEAOrtholog Compara
Negative regulation of multicellular organism growthdefinition[GO:0040015] silver  
  • IEAOrtholog Compara
Negative regulation of smooth muscle contractiondefinition[GO:0045986] silver  
  • IEAOrtholog Compara
Negative regulation of urine volumedefinition[GO:0035811] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Positive regulation of cAMP biosynthetic processdefinition[GO:0030819]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Positive regulation of cAMP-mediated signalingdefinition[GO:0043950]  
1
  • IDAUniProtKB
Positive regulation of cation channel activitydefinition[GO:2001259] silver  
  • IEAOrtholog Compara
Positive regulation of cell growth involved in cardiac muscle cell developmentdefinition[GO:0061051] silver  
  • IEAOrtholog Compara
Positive regulation of heart rate by epinephrine-norepinephrinedefinition[GO:0001996] silver  
  • IEAOrtholog Compara
Positive regulation of Ras GTPase activitydefinition[GO:0032320]  
1
  • IDAUniProtKB
Positive regulation of renin secretion into blood streamdefinition[GO:1900135] silver  
  • IEAOrtholog Compara
Positive regulation of saliva secretiondefinition[GO:0046878] silver  
  • IEAOrtholog Compara
Positive regulation of systemic arterial blood pressuredefinition[GO:0003084] silver  
  • IEAOrtholog Compara
Positive regulation of the force of heart contraction by norepinephrinedefinition[GO:0003061] silver  
  • IEAOrtholog Compara
Protein localization to organelledefinition[GO:0033365] silver  
  • IEAOrtholog Compara
Regulation of calcium ion transportdefinition[GO:0051924] silver  
  • IEAOrtholog Compara
Regulation of cardiac muscle cell contractiondefinition[GO:0086004] silver  
  • IEAOrtholog Compara
Regulation of inhibitory postsynaptic membrane potentialdefinition[GO:0060080] silver  
  • IEAOrtholog Compara
Response to colddefinition[GO:0009409] silver  
  • IEAOrtholog Compara
Rho protein signal transductiondefinition[GO:0007266] silver  
  • IEAOrtholog Compara
Sensory perception of paindefinition[GO:0019233] silver  
  • IEAOrtholog Compara
Vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressuredefinition[GO:0002025] silver  
  • IEAOrtholog Compara
Wound healingdefinition[GO:0042060] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+153  
Dilated cardiomyopathy  hsa05414+153  
Endocytosis  hsa04144+153  
Gap junction  hsa04540+153  
Neuroactive ligand-receptor interaction  hsa04080+153  
Salivary secretion  hsa04970+153  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Beta-1_adrenergic_receptor
GenomeRNAi: 153
PRO: PR:P08588
Chemistry
GuidetoPHARMACOLOGY: 28