ADRB1 - Beta-1 adrenergic receptor - human protein (Function)
 
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ADRB1 »  Beta-1 adrenergic receptor
 
Protein also known as:  Beta-1 adrenoreceptor (Beta-1 adrenoceptor).
Gene name:  ADRB1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.  
2
  • UniProtKB
GO molecular function 
Alpha-2A adrenergic receptor bindingdefinition[GO:0031694]  
1
  • BHF-UCL
Beta-adrenergic receptor activitydefinition[GO:0004939]  
1
  • PINC
Beta1-adrenergic receptor activitydefinition[GO:0004940] silver  
1
  • Ortholog Compara
Epinephrine bindingdefinition[GO:0051379]  
1
  • RefGenome
Norepinephrine bindingdefinition[GO:0051380]  
1
  • RefGenome
PDZ domain bindingdefinition[GO:0030165]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • BHF-UCL
Ras guanyl-nucleotide exchange factor activitydefinition[GO:0005088]  
1
  • UniProtKB
Receptor signaling protein activitydefinition[GO:0005057]  
1
  • UniProtKB
GO biological process 
Activation of adenylate cyclase activitydefinition[GO:0007190]  
1
  • PINC
Adenylate cyclase-activating adrenergic receptor signaling pathwaydefinition[GO:0071880]  
1
  • UniProtKB
Brown fat cell differentiationdefinition[GO:0050873] silver  
1
  • Ortholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • RefGenome
Diet induced thermogenesisdefinition[GO:0002024] silver  
1
  • Ortholog Compara
Fear responsedefinition[GO:0042596] silver  
1
  • Ortholog Compara
Heat generationdefinition[GO:0031649] silver  
1
  • Ortholog Compara
Intracellular signal transductiondefinition[GO:0035556]  
1
  • GOC
Negative regulation of multicellular organism growthdefinition[GO:0040015] silver  
1
  • Ortholog Compara
Positive regulation of cAMP biosynthetic processdefinition[GO:0030819]  
2
  • BHF-UCL
  • UniProtKB
Positive regulation of cAMP-mediated signalingdefinition[GO:0043950]  
1
  • UniProtKB
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • UniProtKB
Positive regulation of heart rate by epinephrine-norepinephrinedefinition[GO:0001996]  
1
  • RefGenome
Positive regulation of the force of heart contraction by epinephrine-norepinephrinedefinition[GO:0001997] silver  
1
  • Ortholog Compara
Response to colddefinition[GO:0009409] silver  
1
  • Ortholog Compara
Temperature homeostasisdefinition[GO:0001659]  
1
  • RefGenome
Vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressuredefinition[GO:0002025]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+153  
Dilated cardiomyopathy  hsa05414+153  
Endocytosis  hsa04144+153  
Gap junction  hsa04540+153  
Neuroactive ligand-receptor interaction  hsa04080+153  
Salivary secretion  hsa04970+153  
According to Reactome, this protein belongs to the following pathways:
Adrenoceptors  R-HSA-390696  
G alpha (s) signalling events  R-HSA-418555  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Beta-1_adrenergic_receptor
GenomeRNAi: 153
PRO: PR:P08588
Chemistry
GuidetoPHARMACOLOGY: 28