FGF4 - Fibroblast growth factor 4 - human protein (Function)
 
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FGF4 »  Fibroblast growth factor 4  (FGF-4)
 
Protein also known as:  Heparin secretory-transforming protein 1 (HST).
Gene name:  FGF4
Entry whose protein(s) existence is based on evidence at protein level
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1 34 2
GENE REF ISO

Function

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Overview 
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.  
2
  • UniProtKB
GO molecular function 
Fibroblast growth factor receptor bindingdefinition[GO:0005104] silver  
1
  • Ortholog Compara
Growth factor activitydefinition[GO:0008083]  
1
  • UniProtKB KW
Heparin bindingdefinition[GO:0008201]  
1
  • UniProtKB KW
GO biological process 
Apoptotic process involved in morphogenesisdefinition[GO:0060561] silver  
1
  • Ortholog Compara
Cartilage condensationdefinition[GO:0001502] silver  
1
  • Ortholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Chondroblast differentiationdefinition[GO:0060591]  
1
  • UniProtKB
Cranial suture morphogenesisdefinition[GO:0060363] silver  
1
  • Ortholog Compara
Embryonic hindlimb morphogenesisdefinition[GO:0035116] silver  
1
  • Ortholog Compara
Fibroblast growth factor receptor signaling pathwaydefinition[GO:0008543]  
1
  • MGI
Mesenchymal cell proliferationdefinition[GO:0010463]  
1
  • UniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
1
  • Ortholog Compara
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
1
  • Ortholog Compara
Positive regulation of cell divisiondefinition[GO:0051781]  
1
  • UniProtKB KW
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • MGI
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Regulation of endothelial cell chemotaxis to fibroblast growth factordefinition[GO:2000544]  
1
  • UniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Stem cell population maintenancedefinition[GO:0019827] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
MAPK signaling pathway  hsa04010+2249  
Melanoma  hsa05218+2249  
Pathways in cancer  hsa05200+2249  
Regulation of actin cytoskeleton  hsa04810+2249  
According to Reactome, this protein belongs to the following pathways:
Activated point mutants of FGFR2  R-HSA-2033519  
Constitutive Signaling by Aberrant PI3K in Cancer  R-HSA-2219530  
FGFR1c ligand binding and activation  R-HSA-190373  
FGFR2c ligand binding and activation  R-HSA-190375  
FGFR3 mutant receptor activation  R-HSA-2033514  
FGFR3c ligand binding and activation  R-HSA-190372  
FGFR4 ligand binding and activation  R-HSA-190322  
FRS-mediated FGFR1 signaling  R-HSA-5654693  
FRS-mediated FGFR2 signaling  R-HSA-5654700  
FRS-mediated FGFR3 signaling  R-HSA-5654706  
FRS-mediated FGFR4 signaling  R-HSA-5654712  
Negative regulation of FGFR1 signaling  R-HSA-5654726  
Negative regulation of FGFR2 signaling  R-HSA-5654727  
Negative regulation of FGFR3 signaling  R-HSA-5654732  
Negative regulation of FGFR4 signaling  R-HSA-5654733  
Phospholipase C-mediated cascade, FGFR2  R-HSA-5654221  
Phospholipase C-mediated cascade, FGFR3  R-HSA-5654227  
Phospholipase C-mediated cascade, FGFR4  R-HSA-5654228  
Phospholipase C-mediated cascade: FGFR1  R-HSA-5654219  
PI-3K cascade:FGFR1  R-HSA-5654689  
PI-3K cascade:FGFR2  R-HSA-5654695  
PI-3K cascade:FGFR3  R-HSA-5654710  
PI-3K cascade:FGFR4  R-HSA-5654720  
PI3K Cascade  R-HSA-109704  
PIP3 activates AKT signaling  R-HSA-1257604  
RAF/MAP kinase cascade  R-HSA-5673001  
SHC-mediated cascade:FGFR1  R-HSA-5654688  
SHC-mediated cascade:FGFR2  R-HSA-5654699  
SHC-mediated cascade:FGFR3  R-HSA-5654704  
SHC-mediated cascade:FGFR4  R-HSA-5654719  
Signaling by activated point mutants of FGFR1  R-HSA-1839122  
Signaling by activated point mutants of FGFR3  R-HSA-1839130  
Signaling by FGFR1 in disease  R-HSA-5655302  
Signaling by FGFR2 in disease  R-HSA-5655253  
Signaling by FGFR3 in disease  R-HSA-5655332  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Molecular function 
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Mitogen  definition   [KW-0497]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FGF4
GenomeRNAi: 2249
PRO: PR:P08620