FGF4 - Fibroblast growth factor 4 - human protein (Function)
 
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FGF4 »  Fibroblast growth factor 4  (FGF-4)
 
Protein also known as:  Heparin secretory-transforming protein 1 (HST).
Gene name:  FGF4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.  
1
  • CuratedUniProtKB
GO molecular function 
Fibroblast growth factor receptor bindingdefinition[GO:0005104] silver  
  • IEAOrtholog Compara
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
Heparin bindingdefinition[GO:0008201]  
  • IEAUniProtKB KW
GO biological process 
Apoptotic process involved in morphogenesisdefinition[GO:0060561] silver  
  • IEAOrtholog Compara
Cartilage condensationdefinition[GO:0001502] silver  
  • IEAOrtholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Chondroblast differentiationdefinition[GO:0060591]  
1
  • IDAUniProtKB
Cranial suture morphogenesisdefinition[GO:0060363] silver  
  • IEAOrtholog Compara
Embryonic hindlimb morphogenesisdefinition[GO:0035116] silver  
  • IEAOrtholog Compara
Fibroblast growth factor receptor signaling pathwaydefinition[GO:0008543]  
1
  • IGIMGI
Mesenchymal cell proliferationdefinition[GO:0010463]  
1
  • IDAUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
  • IEAOrtholog Compara
Positive regulation of cell divisiondefinition[GO:0051781]  
  • IEAUniProtKB KW
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IGIMGI
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • IDAUniProtKB
Positive regulation of protein phosphorylationdefinition[GO:0001934] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Stem cell maintenancedefinition[GO:0019827] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
MAPK signaling pathway  hsa04010+2249  
Melanoma  hsa05218+2249  
Pathways in cancer  hsa05200+2249  
Regulation of actin cytoskeleton  hsa04810+2249  
According to Reactome, this protein belongs to the following pathways:
Activated point mutants of FGFR2  REACT_120863  
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
FGFR1c ligand binding and activation  REACT_9515  
FGFR2c ligand binding and activation  REACT_9413  
FGFR3c ligand binding and activation  REACT_9510  
FGFR4 ligand binding and activation  REACT_9452  
FRS2-mediated cascade  REACT_21247  
Negative regulation of FGFR signaling  REACT_111184  
Phospholipase C-mediated cascade  REACT_21310  
PI-3K cascade  REACT_21270  
PI3K Cascade  REACT_976  
PIP3 activates AKT signaling  REACT_75829  
SHC-mediated cascade  REACT_21374  
Signaling by activated point mutants of FGFR1  REACT_121153  
Signaling by activated point mutants of FGFR3  REACT_121337  
Signaling by FGFR mutants  REACT_121398  
Signaling by FGFR3 mutants  REACT_121249  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Molecular function 
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Mitogen  definition   [KW-0497]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FGF4
GenomeRNAi: 2249
PRO: PR:P08620