HCK - Tyrosine-protein kinase HCK - human protein (Function)
 
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HCK »  Tyrosine-protein kinase HCK   [ EC 2.7.10.2 ]
 
Protein also known as:  Hematopoietic cell kinase.
Gene name:  HCK
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.  
20
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
17
  • IntAct
  • UniProtKB
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • RefGenome
GO biological process 
Cell adhesiondefinition[GO:0007155]  
1
  • UniProtKB
Cell differentiationdefinition[GO:0030154]  
1
  • RefGenome
Cellular response to peptide hormone stimulusdefinition[GO:0071375]  
1
  • RefGenome
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • UniProtKB
Inflammatory responsedefinition[GO:0006954]  
1
  • UniProtKB KW
Innate immune responsedefinition[GO:0045087]  
1
  • RefGenome
Innate immune response-activating signal transductiondefinition[GO:0002758]  
1
  • UniProtKB
Integrin-mediated signaling pathwaydefinition[GO:0007229]  
1
  • UniProtKB
Interferon-gamma-mediated signaling pathwaydefinition[GO:0060333]  
1
  • UniProtKB
Leukocyte degranulationdefinition[GO:0043299]  
1
  • UniProtKB
Leukocyte migration involved in immune responsedefinition[GO:0002522]  
1
  • UniProtKB
Lipopolysaccharide-mediated signaling pathwaydefinition[GO:0031663]  
1
  • UniProtKB
Mesoderm developmentdefinition[GO:0007498]  
1
  • PINC
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Peptidyl-tyrosine autophosphorylationdefinition[GO:0038083]  
1
  • RefGenome
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • UniProtKB
Positive regulation of actin cytoskeleton reorganizationdefinition[GO:2000251]  
2
  • UniProtKB
Positive regulation of actin filament polymerizationdefinition[GO:0030838]  
1
  • UniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • UniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • UniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • PINC
Regulation of cell shapedefinition[GO:0008360]  
2
  • UniProtKB
Regulation of inflammatory responsedefinition[GO:0050727]  
1
  • UniProtKB
Regulation of phagocytosisdefinition[GO:0050764]  
1
  • UniProtKB
Regulation of podosome assemblydefinition[GO:0071801]  
1
  • UniProtKB
Regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051090]  
1
  • UniProtKB
Respiratory burst after phagocytosisdefinition[GO:0045728]  
1
  • UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.2: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
10
  • UniProtKB
  • PROSITE-ProRule
It is regulated in the following manner
Subject to autoinhibition, mediated by intramolecular interactions involving the SH2 and SH3 domains. Kinase activity is also regulated by phosphorylation at regulatory tyrosine residues. Phosphorylation at Tyr-411 is required for optimal activity. Phosphorylation at Tyr-522 inhibits kinase activity. Inhibited by PP1 and A-770041.  
10
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+3055  
Fc gamma R-mediated phagocytosis  hsa04666+3055  
According to Reactome, this protein belongs to the following pathways:
FCGR activation  REACT_160274  
Nef and signal transduction  REACT_11068  
Regulation of signaling by CBL  REACT_23787  
 

Keywords

Biological process 
Exocytosis  definition   [KW-0268]
Host-virus interaction  definition   [KW-0945]
Immunity  definition   [KW-0391]
Inflammatory response  definition   [KW-0395]
Innate immunity  definition   [KW-0399]
Phagocytosis  definition   [KW-0581]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: HCK
GenomeRNAi: 3055
PRO: PR:P08631
Chemistry
GuidetoPHARMACOLOGY: 2032