NFIC - Nuclear factor 1 C-type - human protein (Function)
 
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Protein
Gene
References

 
NFIC »  Nuclear factor 1 C-type  (NF1-C)
 
Protein also known as:  CCAAT-box-binding transcription factor (CTF).
Gene name:  NFIC
Family name: CTF/NF-I
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 46 6
GENE REF ISO

Function

 show evidences
Overview 
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.  
1
  • UniProtKB
GO molecular function 
Double-stranded DNA bindingdefinition[GO:0003690] silver  
1
  • Ortholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • NTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • NTNU_SB
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981]  
1
  • RefGenome
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • MGI
GO biological process 
DNA replicationdefinition[GO:0006260]  
1
  • UniProtKB KW
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
2
  • UniProtKB
  • MGI
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • UniProtKB
  • MGI
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • PINC
Pathways 
According to Reactome, this protein belongs to the following pathways:
RNA Polymerase III Abortive And Retractive Initiation  REACT_22339  
RNA Polymerase III Transcription Termination  REACT_63  
 

Keywords

Biological process 
DNA replication  definition   [KW-0235]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NFIC_(gene)
GenomeRNAi: 4782
PRO: PR:P08651