CYP21A2 - Steroid 21-hydroxylase - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CYP21A2 »  Steroid 21-hydroxylase   [ EC 1.14.99.10 ]
 
Protein also known as:  Cytochrome P450-C21B.
Gene name:  CYP21A2
Family name: Cytochrome P450
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 183 2
GENE REF ISO

Function

 show evidences
Overview 
Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.  
  • CuratedUniProtKB
GO molecular function 
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Steroid 21-monooxygenase activitydefinition[GO:0004509]  
  • IEAEC 2 GO
Steroid bindingdefinition[GO:0005496]  
  • IEAUniProtKB KW
Steroid hydroxylase activitydefinition[GO:0008395]  
1
  • TASPINC
GO biological process 
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.99.10: A C(21) steroid + (reduced NADPH--hemoprotein reductase) + O(2) a 21-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Heme group.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+1589  
Steroid hormone biosynthesis  hsa00140+1589  
According to Reactome, this protein belongs to the following pathways:
Endogenous sterols  REACT_13812  
Glucocorticoid biosynthesis  REACT_11036  
Mineralocorticoid biosynthesis  REACT_11047  
 
More information is available from:
 

Keywords

Biological process 
Steroidogenesis  definition   [KW-0755]
Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: 21-Hydroxylase
GenomeRNAi: 1589
PRO: PR:P08686