GNAI3 - Guanine nucleotide-binding protein G(k) subunit alpha - human protein (Function)
 
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GNAI3 »  Guanine nucleotide-binding protein G(k) subunit alpha
 
Protein also known as:  G(i) alpha-3.
Gene name:  GNAI3
Family name: G-alpha » G(i/o/t/z)
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor-regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.  
1
  • CuratedUniProtKB
GO molecular function 
G-protein beta/gamma-subunit complex bindingdefinition[GO:0031683] silver  
  • IBARefGenome
G-protein coupled serotonin receptor bindingdefinition[GO:0031821] silver  
  • IBARefGenome
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
GTPase activating protein bindingdefinition[GO:0032794] silver  
  • IEAOrtholog Compara
GTPase activitydefinition[GO:0003924] silver  
  • IBARefGenome
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAOrtholog Compara
Signal transducer activitydefinition[GO:0004871] silver  
  • IBARefGenome
GO biological process 
Cell cycledefinition[GO:0007049]  
  • IEAUniProtKB KW
Cell divisiondefinition[GO:0051301]  
1
  • IDAUniProtKB
Negative regulation of adenylate cyclase activitydefinition[GO:0007194]  
1
  • TASPINC
Transportdefinition[GO:0006810]  
1
  • NASPINC
Vesicle fusiondefinition[GO:0006906] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+2773  
Chagas disease (American trypanosomiasis)  hsa05142+2773  
Chemokine signaling pathway  hsa04062+2773  
Cholinergic synapse  hsa04725+2773  
Dopaminergic synapse  hsa04728+2773  
GABAergic synapse  hsa04727+2773  
Gap junction  hsa04540+2773  
Gastric acid secretion  hsa04971+2773  
Glutamatergic synapse  hsa04724+2773  
Leukocyte transendothelial migration  hsa04670+2773  
Long-term depression  hsa04730+2773  
Melanogenesis  hsa04916+2773  
Pertussis  hsa05133+2773  
Progesterone-mediated oocyte maturation  hsa04914+2773  
Tight junction  hsa04530+2773  
Toxoplasmosis  hsa05145+2773  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Neuronal System  REACT_13685  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Molecular function 
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GNAI3
GenomeRNAi: 2773
PRO: PR:P08754