ANXA5 - Annexin A5 - human protein (Function)
 
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Protein
Gene
References

 
ANXA5 »  Annexin A5
 
Protein also known as:  Placental anticoagulant protein I (PAP-I).
Gene name:  ANXA5
Family name: Annexin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.  
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  • UniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
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  • InterPro 2 GO
Calcium-dependent phospholipid bindingdefinition[GO:0005544]  
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  • UniProtKB
Phospholipase inhibitor activitydefinition[GO:0004859]  
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  • PINC
Phospholipid bindingdefinition[GO:0005543]  
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  • PINC
GO biological process 
Activation of mitophagy in response to mitochondrial depolarizationdefinition[GO:0098779]  
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  • ParkinsonsUK-UCL
Blood coagulationdefinition[GO:0007596]  
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  • UniProtKB KW
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of catalytic activitydefinition[GO:0043086]  
1
  • GOC
Negative regulation of coagulationdefinition[GO:0050819] silver  
1
  • InterPro 2 GO
Positive regulation of defense response to virus by hostdefinition[GO:0002230]  
1
  • ParkinsonsUK-UCL
Response to organic substancedefinition[GO:0010033] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • UniProtKB
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Annexin_A5
GenomeRNAi: 308
PRO: PR:P08758