RPSA - 40S ribosomal protein SA - human protein (Function)
 
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RPSA »  40S ribosomal protein SA
 
Protein also known as:  Multidrug resistance-associated protein MGr1-Ag.
Gene name:  RPSA
Family name: Ribosomal protein S2P
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.  
4
  • UniProtKB
  • HAMAP-Rule
(Microbial infection) Acts as a receptor for the adeno-associated viruses 2,3,8 and 9, dengue virus, Sindbis virus and Venezuelan equine encephalitis virus (PubMed1385835, PubMed15507651, PubMed16973587). Also acts as a receptor for pathogenic prion protein and bacteria (PubMed9396609, PubMed11689427, PubMed15516338).  
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  • UniProtKB
GO molecular function 
Laminin bindingdefinition[GO:0043236]  
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  • UniProtKB Annot
Laminin receptor activitydefinition[GO:0005055]  
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  • UniProtKB Annot
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
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  • IntAct
  • UniProtKB
Ribosome bindingdefinition[GO:0043022]  
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  • UniProtKB
Structural constituent of ribosomedefinition[GO:0003735]  
1
  • RefGenome
Virus receptor activitydefinition[GO:0001618]  
1
  • UniProtKB KW
GO biological process 
Cell adhesiondefinition[GO:0007155]  
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  • UniProtKB Annot
Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)definition[GO:0000447]  
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  • RefGenome
Endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)definition[GO:0000461]  
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  • RefGenome
Ribosomal small subunit assemblydefinition[GO:0000028]  
1
  • RefGenome
rRNA export from nucleusdefinition[GO:0006407]  
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  • RefGenome
Translationdefinition[GO:0006412]  
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  • UniProtKB
  • RefGenome
Viral entry into host celldefinition[GO:0046718]  
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  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Ribosome  hsa03010+3921  
According to Reactome, this protein belongs to the following pathways:
Eukaryotic Translation Termination  R-HSA-72764  
Formation of a pool of free 40S subunits  R-HSA-72689  
Formation of the ternary complex, and subsequently, the 43S complex  R-HSA-72695  
GTP hydrolysis and joining of the 60S ribosomal subunit  R-HSA-72706  
L13a-mediated translational silencing of Ceruloplasmin expression  R-HSA-156827  
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)  R-HSA-975957  
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)  R-HSA-975956  
Peptide chain elongation  R-HSA-156902  
Ribosomal scanning and start codon recognition  R-HSA-72702  
SRP-dependent cotranslational protein targeting to membrane  R-HSA-1799339  
Translation initiation complex formation  R-HSA-72649  
Viral mRNA Translation  R-HSA-192823  
Note 
This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.  
1
  • UniProtKB
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Molecular function 
Host cell receptor for virus entry  definition   [KW-1183]
Receptor  definition   [KW-0675]
Ribonucleoprotein  definition   [KW-0687]
Ribosomal protein  definition   [KW-0689]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Ribosomal_protein_SA
GenomeRNAi: 3921
PRO: PR:P08865