RPSA - 40S ribosomal protein SA - human protein (Function)
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RPSA »  40S ribosomal protein SA
Protein also known as:  Multidrug resistance-associated protein MGr1-Ag.
Gene name:  RPSA
Family name: Ribosomal protein S2P
Entry whose protein(s) existence is based on evidence at protein level
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Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.  
  • CuratedUniProtKB
GO molecular function 
Laminin bindingdefinition[GO:0043236]  
  • IEAUniProtKB Annot
Laminin receptor activitydefinition[GO:0005055]  
  • IEAUniProtKB Annot
Poly(A) RNA bindingdefinition[GO:0044822]  
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
  • IPIUniProtKB
Ribosome bindingdefinition[GO:0043022]  
  • IPIUniProtKB
Structural constituent of ribosomedefinition[GO:0003735] silver  
  • IBARefGenome
GO biological process 
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB Annot
Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)definition[GO:0000447] silver  
  • IBARefGenome
Endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)definition[GO:0000461] silver  
  • IBARefGenome
Ribosomal small subunit assemblydefinition[GO:0000028] silver  
  • IBARefGenome
rRNA export from nucleusdefinition[GO:0006407] silver  
  • IBARefGenome
  • ICUniProtKB
  • IBARefGenome
According to KEGG, this protein belongs to the following pathway:
Ribosome  hsa03010+3921  
According to Reactome, this protein belongs to the following pathways:
Eukaryotic Translation Termination  REACT_1986  
Formation of a pool of free 40S subunits  REACT_1797  
Formation of the ternary complex, and subsequently, the 43S complex  REACT_1079  
GTP hydrolysis and joining of the 60S ribosomal subunit  REACT_2085  
L13a-mediated translational silencing of Ceruloplasmin expression  REACT_79  
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)  REACT_75822  
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)  REACT_75768  
Peptide chain elongation  REACT_1404  
Ribosomal scanning and start codon recognition  REACT_931  
SRP-dependent cotranslational protein targeting to membrane  REACT_115902  
Translation initiation complex formation  REACT_1979  
Viral mRNA Translation  REACT_9491  
This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.  
  • CuratedUniProtKB


Molecular function 
Receptor  definition   [KW-0675]
Ribonucleoprotein  definition   [KW-0687]
Ribosomal protein  definition   [KW-0689]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: Ribosomal_protein_SA
GenomeRNAi: 3921
PRO: PR:P08865