HTR1A - 5-hydroxytryptamine receptor 1A - human protein (Function)
 
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HTR1A »  5-hydroxytryptamine receptor 1A  (5-HT1A)
 
Protein also known as:  Serotonin receptor 1A.
Gene name:  HTR1A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 177 1
GENE REF ISO

Function

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Overview 
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.  
4
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Serotonin receptor activitydefinition[GO:0004993]  
2
  • IMPUniProtKB
GO biological process 
Adenylate cyclase-inhibiting serotonin receptor signaling pathwaydefinition[GO:0007198]  
1
  • IDAUniProtKB
Behavioral fear responsedefinition[GO:0001662]  
  • ISSOrtholog Curator
Cell proliferationdefinition[GO:0008283] silver  
  • IEAInterPro 2 GO
Exploration behaviordefinition[GO:0035640]  
  • ISSOrtholog Curator
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IMPUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • TASPINC
Regulation of behaviordefinition[GO:0050795] silver  
  • IEAInterPro 2 GO
Regulation of dopamine metabolic processdefinition[GO:0042053]  
  • ISSOrtholog Curator
Regulation of hormone secretiondefinition[GO:0046883] silver  
  • IEAInterPro 2 GO
Regulation of serotonin secretiondefinition[GO:0014062]  
  • ISSOrtholog Curator
Serotonin metabolic processdefinition[GO:0042428]  
  • ISSOrtholog Curator
Serotonin receptor signaling pathwaydefinition[GO:0007210]  
  • ISSOrtholog Curator
Vasoconstrictiondefinition[GO:0042310] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+3350  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Behavior  definition   [KW-0085]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 3350
PRO: PR:P08908
Chemistry
GuidetoPHARMACOLOGY: 1