ADRA2A - Alpha-2A adrenergic receptor - human protein (Function)
 
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ADRA2A »  Alpha-2A adrenergic receptor
 
Protein also known as:  Alpha-2 adrenergic receptor subtype C10.
Gene name:  ADRA2A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 101 1
GENE REF ISO

Function

 show evidences
Overview 
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.  
1
  • CuratedUniProtKB
GO molecular function 
Alpha-1B adrenergic receptor bindingdefinition[GO:0031692]  
  • ISSOrtholog Curator
Alpha-2C adrenergic receptor bindingdefinition[GO:0031696]  
1
  • IPIBHF-UCL
Alpha2-adrenergic receptor activitydefinition[GO:0004938]  
2
  • IDABHF-UCL
Epinephrine bindingdefinition[GO:0051379]  
2
  • IDABHF-UCL
Heterotrimeric G-protein bindingdefinition[GO:0032795]  
1
  • IDABHF-UCL
Norepinephrine bindingdefinition[GO:0051380]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
  • ISSOrtholog Curator
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDABHF-UCL
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIBHF-UCL
Thioesterase bindingdefinition[GO:0031996]  
1
  • IPIBHF-UCL
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036]  
1
  • TASPINC
Activation of MAPK activity by adrenergic receptor signaling pathwaydefinition[GO:0071883]  
1
  • IDABHF-UCL
Activation of protein kinase activitydefinition[GO:0032147]  
1
  • IDABHF-UCL
Activation of protein kinase B activitydefinition[GO:0032148]  
1
  • IDABHF-UCL
Acute inflammatory responsedefinition[GO:0002526] silver  
  • IEAOrtholog Compara
Adenylate cyclase-inhibiting adrenergic receptor signaling pathwaydefinition[GO:0071881]  
1
  • IDABHF-UCL
Cellular component movementdefinition[GO:0006928]  
1
  • TASPINC
Cellular response to hormone stimulusdefinition[GO:0032870]  
1
  • IGIBHF-UCL
DNA replicationdefinition[GO:0006260] silver  
  • IEAOrtholog Compara
Epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwaydefinition[GO:0035625]  
2
  • IDABHF-UCL
Fear responsedefinition[GO:0042596] silver  
  • IEAOrtholog Compara
Female pregnancydefinition[GO:0007565] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • ISSBHF-UCL
Glucose homeostasisdefinition[GO:0042593]  
1
  • IMPBHF-UCL
Intestinal absorptiondefinition[GO:0050892]  
1
  • TASBHF-UCL
Negative regulation of adenylate cyclase activitydefinition[GO:0007194]  
1
  • ISSBHF-UCL
Negative regulation of adrenergic receptor signaling pathwaydefinition[GO:0071878]  
  • ISSOrtholog Curator
Negative regulation of calcium ion transmembrane transporter activitydefinition[GO:1901020]  
1
  • ISSBHF-UCL
Negative regulation of calcium ion transportdefinition[GO:0051926]  
  • ISSOrtholog Curator
Negative regulation of calcium ion-dependent exocytosisdefinition[GO:0045955]  
1
  • ICBHF-UCL
Negative regulation of cAMP biosynthetic processdefinition[GO:0030818]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Negative regulation of epinephrine secretiondefinition[GO:0032811]  
1
  • NASBHF-UCL
Negative regulation of insulin secretiondefinition[GO:0046676]  
1
  • IMPBHF-UCL
Negative regulation of insulin secretion involved in cellular response to glucose stimulusdefinition[GO:0061179]  
1
  • IMPBHF-UCL
Negative regulation of lipid catabolic processdefinition[GO:0050995]  
1
  • IGIBHF-UCL
Negative regulation of norepinephrine secretiondefinition[GO:0010700]  
2
  • TASBHF-UCL
Negative regulation of uterine smooth muscle contractiondefinition[GO:0070473] silver  
  • IEAOrtholog Compara
Phospholipase C-activating adrenergic receptor signaling pathwaydefinition[GO:0071882]  
1
  • IDABHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IMPBHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • TASPINC
Positive regulation of cytokine productiondefinition[GO:0001819]  
1
  • IDABHF-UCL
Positive regulation of epidermal growth factor-activated receptor activitydefinition[GO:0045741]  
1
  • IDABHF-UCL
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
1
  • IDABHF-UCL
Positive regulation of membrane protein ectodomain proteolysisdefinition[GO:0051044]  
1
  • IDABHF-UCL
Positive regulation of potassium ion transportdefinition[GO:0043268]  
1
  • ISSBHF-UCL
Positive regulation of vasodilationdefinition[GO:0045909] silver  
  • IEAOrtholog Compara
Positive regulation of wound healingdefinition[GO:0090303]  
1
  • IMPBHF-UCL
Ras protein signal transductiondefinition[GO:0007265]  
1
  • TASPINC
Regulation of vasoconstrictiondefinition[GO:0019229] silver  
  • IEAInterPro 2 GO
Rho protein signal transductiondefinition[GO:0007266]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
2
  • TASPINC
Thermoceptiondefinition[GO:0050955] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+150  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Metabolism  REACT_111217  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Alpha-2A_adrenergic_receptor
GenomeRNAi: 150
PRO: PR:P08913
Chemistry
GuidetoPHARMACOLOGY: 25