SNRPA - U1 small nuclear ribonucleoprotein A - human protein (Function)
 
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Protein
Gene
References

 
SNRPA »  U1 small nuclear ribonucleoprotein A  (U1A)
 
Gene name:  SNRPA
Family name: RRM U1 A/B''
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 72 1
GENE REF ISO

Function

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Overview 
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.  
  • CuratedUniProtKB
GO molecular function 
Nucleotide bindingdefinition[GO:0000166] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIHGNC
RNA bindingdefinition[GO:0003723]  
1
  • IDAUniProtKB
snRNA bindingdefinition[GO:0017069] silver  
  • IEAInterPro 2 GO
GO biological process 
mRNA splicing, via spliceosomedefinition[GO:0000398]  
1
  • ICHGNC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Spliceosome  hsa03040+6626  
According to Reactome, this protein belongs to the following pathways:
Gene Expression  REACT_71  
mRNA Processing  REACT_1675  
 

Keywords

Biological process 
mRNA processing  definition   [KW-0507]
mRNA splicing  definition   [KW-0508]
Molecular function 
Ribonucleoprotein  definition   [KW-0687]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links