FGF2 - Fibroblast growth factor 2 - human protein (Function)
 
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FGF2 »  Fibroblast growth factor 2  (FGF-2)
 
Protein also known as:  Heparin-binding growth factor 2 (HBGF-2).
Gene name:  FGF2
Entry whose protein(s) existence is based on evidence at protein level
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1 481 4
GENE REF ISO

Function

 show evidences
Overview 
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.  
2
  • CuratedUniProtKB
GO molecular function 
Chemoattractant activitydefinition[GO:0042056]  
1
  • IDABHF-UCL
Cytokine activitydefinition[GO:0005125]  
1
  • IDABHF-UCL
Fibroblast growth factor bindingdefinition[GO:0017134] silver  
  • IEAOrtholog Compara
Fibroblast growth factor receptor bindingdefinition[GO:0005104]  
1
  • IPIMGI
Growth factor activitydefinition[GO:0008083]  
1
  • IDABHF-UCL
Heparin bindingdefinition[GO:0008201]  
  • IEAUniProtKB KW
Ligand-dependent nuclear receptor transcription coactivator activitydefinition[GO:0030374]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
11
  • IPIIntAct
  • IPIUniProtKB
  • IPIHGNC
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • TASPINC
Activation of MAPKK activitydefinition[GO:0000186] silver  
  • IEAOrtholog Compara
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658]  
1
  • IDAUniProtKB
C21-steroid hormone biosynthetic processdefinition[GO:0006700] silver  
  • IEAOrtholog Compara
Cell migration involved in sprouting angiogenesisdefinition[GO:0002042]  
2
  • IGIBHF-UCL
Chemotaxisdefinition[GO:0006935]  
1
  • TASPINC
Chondroblast differentiationdefinition[GO:0060591]  
1
  • IDAUniProtKB
Corticotropin hormone secreting cell differentiationdefinition[GO:0060128] silver  
  • IEAOrtholog Compara
Embryonic morphogenesisdefinition[GO:0048598]  
1
  • TASDFLAT
Fibroblast growth factor receptor signaling pathwaydefinition[GO:0008543]  
3
  • IDAUniProtKB
  • IPIMGI
Glial cell differentiationdefinition[GO:0010001] silver  
  • IEAOrtholog Compara
Hyaluronan catabolic processdefinition[GO:0030214]  
1
  • IDAUniProtKB
Inositol phosphate biosynthetic processdefinition[GO:0032958]  
1
  • IDADFLAT
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Mammary gland epithelial cell differentiationdefinition[GO:0060644] silver  
  • IEAOrtholog Compara
MAPK import into nucleusdefinition[GO:0000189] silver  
  • IEAOrtholog Compara
Negative regulation of blood vessel endothelial cell migrationdefinition[GO:0043537]  
1
  • IDABHF-UCL
Negative regulation of cell deathdefinition[GO:0060548]  
1
  • IDAUniProtKB
Negative regulation of cell growthdefinition[GO:0030308] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of fibroblast migrationdefinition[GO:0010764]  
1
  • IDAUniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892] silver  
  • IEAOrtholog Compara
Negative regulation of wound healingdefinition[GO:0061045]  
1
  • IDAUniProtKB
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Organ inductiondefinition[GO:0001759] silver  
  • IEAOrtholog Compara
Organ morphogenesisdefinition[GO:0009887]  
1
  • TASPINC
Phosphatidylinositol biosynthetic processdefinition[GO:0006661]  
1
  • IDADFLAT
Positive chemotaxisdefinition[GO:0050918]  
1
  • IDAGOC
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • IDADFLAT
Positive regulation of blood vessel endothelial cell migrationdefinition[GO:0043536]  
2
  • IDADFLAT
  • IDABHF-UCL
Positive regulation of cardiac muscle cell proliferationdefinition[GO:0060045]  
1
  • IDABHF-UCL
Positive regulation of cell divisiondefinition[GO:0051781]  
  • IEAUniProtKB KW
Positive regulation of cell fate specificationdefinition[GO:0042660]  
1
  • IDAMGI
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IGIMGI
Positive regulation of cerebellar granule cell precursor proliferationdefinition[GO:0021940] silver  
  • IEAOrtholog Compara
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
1
  • IMPBHF-UCL
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • IDAUniProtKB
Positive regulation of osteoblast differentiationdefinition[GO:0045669] silver  
  • IEAOrtholog Compara
Positive regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043552]  
1
  • IDADFLAT
Positive regulation of phospholipase C activitydefinition[GO:0010863]  
1
  • IDADFLAT
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Ras protein signal transductiondefinition[GO:0007265]  
1
  • TASPINC
Regulation of angiogenesisdefinition[GO:0045765]  
1
  • TASDFLAT
Regulation of cell cycledefinition[GO:0051726] silver  
  • IEAOrtholog Compara
Regulation of retinal cell programmed cell deathdefinition[GO:0046668] silver  
  • IEAOrtholog Compara
Release of sequestered calcium ion into cytosoldefinition[GO:0051209]  
1
  • IDADFLAT
Response to axon injurydefinition[GO:0048678] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • NASPINC
Stem cell developmentdefinition[GO:0048864] silver  
  • IEAOrtholog Compara
Substantia nigra developmentdefinition[GO:0021762] silver  
  • IEAOrtholog Compara
Thyroid-stimulating hormone-secreting cell differentiationdefinition[GO:0060129] silver  
  • IEAOrtholog Compara
Wound healingdefinition[GO:0042060]  
1
  • TASDFLAT
Pathways 
According to KEGG, this protein belongs to the following pathways:
MAPK signaling pathway  hsa04010+2247  
Melanoma  hsa05218+2247  
Pathways in cancer  hsa05200+2247  
Regulation of actin cytoskeleton  hsa04810+2247  
According to Reactome, this protein belongs to the following pathways:
Activated point mutants of FGFR2  REACT_120863  
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
FGFR1b ligand binding and activation  REACT_9400  
FGFR1c ligand binding and activation  REACT_9515  
FGFR2c ligand binding and activation  REACT_9413  
FGFR3c ligand binding and activation  REACT_9510  
FGFR4 ligand binding and activation  REACT_9452  
FRS2-mediated cascade  REACT_21247  
Negative regulation of FGFR signaling  REACT_111184  
Non-integrin membrane-ECM interactions  REACT_163874  
Phospholipase C-mediated cascade  REACT_21310  
PI-3K cascade  REACT_21270  
PI3K Cascade  REACT_976  
PIP3 activates AKT signaling  REACT_75829  
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation  REACT_200759  
SHC-mediated cascade  REACT_21374  
Signaling by activated point mutants of FGFR1  REACT_121153  
Signaling by activated point mutants of FGFR3  REACT_121337  
Signaling by FGFR mutants  REACT_121398  
Signaling by FGFR3 mutants  REACT_121249  
Syndecan interactions  REACT_163942  
 

Biophysicochemical properties

Dependence
pH Retains almost half of its activity after treatment at pH 2.0 for 3 hours at 20 degrees Celsius.
Temperature Inactivated after 3 minutes at 60 degrees Celsius or 1 minute at 80 degrees Celsius.

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Differentiation  definition   [KW-0221]
Molecular function 
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Mitogen  definition   [KW-0497]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links