FGF2 - Fibroblast growth factor 2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
FGF2 »  Fibroblast growth factor 2  (FGF-2)
 
Protein also known as:  Heparin-binding growth factor 2 (HBGF-2).
Gene name:  FGF2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 510 4
GENE REF ISO

Function

 show evidences
Overview 
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.  
3
  • UniProtKB
GO molecular function 
Chemoattractant activitydefinition[GO:0042056]  
1
  • BHF-UCL
Cytokine activitydefinition[GO:0005125]  
1
  • BHF-UCL
Fibroblast growth factor receptor bindingdefinition[GO:0005104]  
1
  • MGI
Growth factor activitydefinition[GO:0008083]  
1
  • BHF-UCL
Heparin bindingdefinition[GO:0008201]  
1
  • UniProtKB KW
Ligand-dependent nuclear receptor transcription coactivator activitydefinition[GO:0030374]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
11
  • IntAct
  • UniProtKB
  • HGNC
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • PINC
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658]  
1
  • UniProtKB
Cell migration involved in sprouting angiogenesisdefinition[GO:0002042]  
2
  • BHF-UCL
Chemotaxisdefinition[GO:0006935]  
1
  • PINC
Chondroblast differentiationdefinition[GO:0060591]  
1
  • UniProtKB
Embryonic morphogenesisdefinition[GO:0048598]  
1
  • DFLAT
Fibroblast growth factor receptor signaling pathwaydefinition[GO:0008543]  
3
  • UniProtKB
  • MGI
Growth factor dependent regulation of skeletal muscle satellite cell proliferationdefinition[GO:0014843]  
1
  • AgBase
Hyaluronan catabolic processdefinition[GO:0030214]  
1
  • UniProtKB
Inositol phosphate biosynthetic processdefinition[GO:0032958]  
1
  • DFLAT
Negative regulation of blood vessel endothelial cell migrationdefinition[GO:0043537]  
1
  • BHF-UCL
Negative regulation of cell deathdefinition[GO:0060548]  
1
  • UniProtKB
Negative regulation of fibroblast migrationdefinition[GO:0010764]  
1
  • UniProtKB
Negative regulation of wound healingdefinition[GO:0061045]  
1
  • UniProtKB
Nervous system developmentdefinition[GO:0007399]  
1
  • PINC
Organ morphogenesisdefinition[GO:0009887]  
1
  • PINC
Phosphatidylinositol biosynthetic processdefinition[GO:0006661]  
1
  • DFLAT
Positive chemotaxisdefinition[GO:0050918]  
1
  • GOC
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • DFLAT
Positive regulation of blood vessel endothelial cell migrationdefinition[GO:0043536]  
2
  • DFLAT
  • BHF-UCL
Positive regulation of cardiac muscle cell proliferationdefinition[GO:0060045]  
1
  • BHF-UCL
Positive regulation of cell divisiondefinition[GO:0051781]  
1
  • UniProtKB KW
Positive regulation of cell fate specificationdefinition[GO:0042660]  
1
  • MGI
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • MGI
Positive regulation of endothelial cell chemotaxis to fibroblast growth factordefinition[GO:2000546]  
1
  • UniProtKB
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
2
  • BHF-UCL
  • UniProtKB
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
2
  • UniProtKB
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
1
  • UniProtKB
Positive regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043552]  
1
  • DFLAT
Positive regulation of phospholipase C activitydefinition[GO:0010863]  
1
  • DFLAT
Positive regulation of sprouting angiogenesisdefinition[GO:1903672]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • BHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Ras protein signal transductiondefinition[GO:0007265]  
1
  • PINC
Regulation of angiogenesisdefinition[GO:0045765]  
1
  • DFLAT
Regulation of endothelial cell chemotaxis to fibroblast growth factordefinition[GO:2000544]  
1
  • UniProtKB
Release of sequestered calcium ion into cytosoldefinition[GO:0051209]  
1
  • DFLAT
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Wound healingdefinition[GO:0042060]  
2
  • DFLAT
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
MAPK signaling pathway  hsa04010+2247  
Melanoma  hsa05218+2247  
Pathways in cancer  hsa05200+2247  
Regulation of actin cytoskeleton  hsa04810+2247  
According to Reactome, this protein belongs to the following pathways:
Activated point mutants of FGFR2  REACT_120863  
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
FGFR1b ligand binding and activation  REACT_9400  
FGFR1c ligand binding and activation  REACT_9515  
FGFR2c ligand binding and activation  REACT_9413  
FGFR3c ligand binding and activation  REACT_9510  
FGFR4 ligand binding and activation  REACT_9452  
FRS2-mediated cascade  REACT_21247  
Negative regulation of FGFR signaling  REACT_111184  
Non-integrin membrane-ECM interactions  REACT_163874  
Phospholipase C-mediated cascade  REACT_21310  
PI-3K cascade  REACT_21270  
PI3K Cascade  REACT_976  
PIP3 activates AKT signaling  REACT_75829  
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation  REACT_264617  
SHC-mediated cascade  REACT_21374  
Signaling by activated point mutants of FGFR1  REACT_121153  
Signaling by activated point mutants of FGFR3  REACT_121337  
Signaling by FGFR mutants  REACT_121398  
Signaling by FGFR3 mutants  REACT_121249  
Syndecan interactions  REACT_163942  
 

Biophysicochemical properties

Dependence
pH Retains almost half of its activity after treatment at pH 2.0 for 3 hours at 20 degrees Celsius.
Temperature Inactivated after 3 minutes at 60 degrees Celsius or 1 minute at 80 degrees Celsius.

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Differentiation  definition   [KW-0221]
Molecular function 
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Mitogen  definition   [KW-0497]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links