FGF2 - Fibroblast growth factor 2 - human protein (Function)
 
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FGF2 »  Fibroblast growth factor 2  (FGF-2)
 
Protein also known as:  Heparin-binding growth factor 2 (HBGF-2).
Gene name:  FGF2
Entry whose protein(s) existence is based on evidence at protein level
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1 530 4
GENE REF ISO

Function

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Overview 
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.  
3
  • UniProtKB
GO molecular function 
Chemoattractant activitydefinition[GO:0042056]  
1
  • BHF-UCL
Cytokine activitydefinition[GO:0005125]  
1
  • BHF-UCL
Fibroblast growth factor receptor bindingdefinition[GO:0005104]  
1
  • MGI
Growth factor activitydefinition[GO:0008083]  
1
  • BHF-UCL
Heparin bindingdefinition[GO:0008201]  
1
  • UniProtKB KW
Ligand-dependent nuclear receptor transcription coactivator activitydefinition[GO:0030374]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
11
  • IntAct
  • UniProtKB
  • HGNC
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • PINC
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658]  
1
  • UniProtKB
Cell migration involved in sprouting angiogenesisdefinition[GO:0002042]  
2
  • BHF-UCL
Chemotaxisdefinition[GO:0006935]  
1
  • PINC
Chondroblast differentiationdefinition[GO:0060591]  
1
  • UniProtKB
Embryonic morphogenesisdefinition[GO:0048598]  
1
  • DFLAT
Fibroblast growth factor receptor signaling pathwaydefinition[GO:0008543]  
3
  • UniProtKB
  • MGI
Growth factor dependent regulation of skeletal muscle satellite cell proliferationdefinition[GO:0014843]  
1
  • AgBase
Hyaluronan catabolic processdefinition[GO:0030214]  
1
  • UniProtKB
Inositol phosphate biosynthetic processdefinition[GO:0032958]  
1
  • DFLAT
Negative regulation of blood vessel endothelial cell migrationdefinition[GO:0043537]  
1
  • BHF-UCL
Negative regulation of cell deathdefinition[GO:0060548]  
1
  • UniProtKB
Negative regulation of fibroblast migrationdefinition[GO:0010764]  
1
  • UniProtKB
Negative regulation of wound healingdefinition[GO:0061045]  
1
  • UniProtKB
Nervous system developmentdefinition[GO:0007399]  
1
  • PINC
Organ morphogenesisdefinition[GO:0009887]  
1
  • PINC
Phosphatidylinositol biosynthetic processdefinition[GO:0006661]  
1
  • DFLAT
Positive chemotaxisdefinition[GO:0050918]  
1
  • GOC
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • DFLAT
Positive regulation of blood vessel endothelial cell migrationdefinition[GO:0043536]  
2
  • DFLAT
  • BHF-UCL
Positive regulation of cardiac muscle cell proliferationdefinition[GO:0060045]  
1
  • BHF-UCL
Positive regulation of cell divisiondefinition[GO:0051781]  
1
  • UniProtKB KW
Positive regulation of cell fate specificationdefinition[GO:0042660]  
1
  • MGI
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • MGI
Positive regulation of endothelial cell chemotaxis to fibroblast growth factordefinition[GO:2000546]  
1
  • UniProtKB
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
2
  • BHF-UCL
  • UniProtKB
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
2
  • UniProtKB
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
1
  • UniProtKB
Positive regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043552]  
1
  • DFLAT
Positive regulation of phospholipase C activitydefinition[GO:0010863]  
1
  • DFLAT
Positive regulation of sprouting angiogenesisdefinition[GO:1903672]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • BHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Regulation of angiogenesisdefinition[GO:0045765]  
1
  • DFLAT
Regulation of endothelial cell chemotaxis to fibroblast growth factordefinition[GO:2000544]  
1
  • UniProtKB
Release of sequestered calcium ion into cytosoldefinition[GO:0051209]  
1
  • DFLAT
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Wound healingdefinition[GO:0042060]  
2
  • DFLAT
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
MAPK signaling pathway  hsa04010+2247  
Melanoma  hsa05218+2247  
Pathways in cancer  hsa05200+2247  
Regulation of actin cytoskeleton  hsa04810+2247  
According to Reactome, this protein belongs to the following pathways:
Activated point mutants of FGFR2  R-HSA-2033519  
Constitutive Signaling by Aberrant PI3K in Cancer  R-HSA-2219530  
FGFR1b ligand binding and activation  R-HSA-190370  
FGFR1c ligand binding and activation  R-HSA-190373  
FGFR2b ligand binding and activation  R-HSA-190377  
FGFR2c ligand binding and activation  R-HSA-190375  
FGFR3 mutant receptor activation  R-HSA-2033514  
FGFR3c ligand binding and activation  R-HSA-190372  
FGFR4 ligand binding and activation  R-HSA-190322  
FRS-mediated FGFR1 signaling  R-HSA-5654693  
FRS-mediated FGFR2 signaling  R-HSA-5654700  
FRS-mediated FGFR3 signaling  R-HSA-5654706  
FRS-mediated FGFR4 signaling  R-HSA-5654712  
Negative regulation of FGFR1 signaling  R-HSA-5654726  
Negative regulation of FGFR2 signaling  R-HSA-5654727  
Negative regulation of FGFR3 signaling  R-HSA-5654732  
Negative regulation of FGFR4 signaling  R-HSA-5654733  
Non-integrin membrane-ECM interactions  R-HSA-3000171  
Phospholipase C-mediated cascade, FGFR2  R-HSA-5654221  
Phospholipase C-mediated cascade, FGFR3  R-HSA-5654227  
Phospholipase C-mediated cascade, FGFR4  R-HSA-5654228  
Phospholipase C-mediated cascade: FGFR1  R-HSA-5654219  
PI-3K cascade:FGFR1  R-HSA-5654689  
PI-3K cascade:FGFR2  R-HSA-5654695  
PI-3K cascade:FGFR3  R-HSA-5654710  
PI-3K cascade:FGFR4  R-HSA-5654720  
PI3K Cascade  R-HSA-109704  
PIP3 activates AKT signaling  R-HSA-1257604  
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation  R-HSA-2892247  
RAF/MAP kinase cascade  R-HSA-5673001  
SHC-mediated cascade:FGFR1  R-HSA-5654688  
SHC-mediated cascade:FGFR2  R-HSA-5654699  
SHC-mediated cascade:FGFR3  R-HSA-5654704  
SHC-mediated cascade:FGFR4  R-HSA-5654719  
Signaling by activated point mutants of FGFR1  R-HSA-1839122  
Signaling by activated point mutants of FGFR3  R-HSA-1839130  
Signaling by FGFR1 in disease  R-HSA-5655302  
Signaling by FGFR2 in disease  R-HSA-5655253  
Signaling by FGFR3 in disease  R-HSA-5655332  
Syndecan interactions  R-HSA-3000170  
 

Biophysicochemical properties

Dependence
pH Retains almost half of its activity after treatment at pH 2.0 for 3 hours at 20 degrees Celsius.
Temperature Inactivated after 3 minutes at 60 degrees Celsius or 1 minute at 80 degrees Celsius.

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Differentiation  definition   [KW-0221]
Molecular function 
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Mitogen  definition   [KW-0497]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links