POU2F2 - POU domain, class 2, transcription factor 2 - human protein (Function)
 
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Protein
Gene
References

 
POU2F2 »  POU domain, class 2, transcription factor 2
 
Protein also known as:  Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2.
Gene name:  POU2F2
Entry whose protein(s) existence is based on evidence at protein level
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1 42 5
GENE REF ISO

Function

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Overview 
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR.  
4
  • CuratedUniProtKB
Isoform  Iso 5   Activates the U2 small nuclear RNA (snRNA) promoter.  
4
  • CuratedUniProtKB
GO molecular function 
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDAMGI
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
GO biological process 
Cell maturationdefinition[GO:0048469] silver  
  • IEAOrtholog Compara
Humoral immune responsedefinition[GO:0006959]  
1
  • TASPINC
Immunoglobulin secretion involved in immune responsedefinition[GO:0002380] silver  
  • IEAOrtholog Compara
Mature B cell differentiationdefinition[GO:0002335] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893] silver  
  • IEAOrtholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 5452
PRO: PR:P09086