ENO2 - Gamma-enolase - human protein (Function)
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ENO2 »  Gamma-enolase   [ EC ]
Protein also known as:  2-phospho-D-glycerate hydro-lyase.
Gene name:  ENO2
Family name: Enolase
Entry whose protein(s) existence is based on evidence at protein level
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1 93 2


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Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IEAInterPro 2 GO
Phosphopyruvate hydratase activitydefinition[GO:0004634]  
  • IEAEC 2 GO
GO biological process 
Glycolytic processdefinition[GO:0006096]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2-phospho-D-glycerate phosphoenolpyruvate + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium. Required for catalysis and for stabilizing the dimer.  
  • CuratedUniProtKB
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycolysis / Gluconeogenesis  hsa00010+2026  
Metabolic pathways  hsa01100+2026  
RNA degradation  hsa03018+2026  
According to Reactome, this protein belongs to the following pathways:
Gluconeogenesis  REACT_1520  
Glycolysis  REACT_1383  
More information is available from:


Biological process 
Glycolysis  definition   [KW-0324]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

Enzyme and pathway databases
SABIO-RK: P09104
GeneWiki: Enolase_2
GenomeRNAi: 2026
PRO: PR:P09104