ACAA1 - 3-ketoacyl-CoA thiolase, peroxisomal - human protein (Function)
 
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ACAA1 »  3-ketoacyl-CoA thiolase, peroxisomal   [ EC 2.3.1.16 ]
 
Protein also known as:  Peroxisomal 3-oxoacyl-CoA thiolase.
Gene name:  ACAA1
Family name: Thiolase
Entry whose protein(s) existence is based on evidence at protein level
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1 25 2
GENE REF ISO

Function

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GO molecular function 
Acetyl-CoA C-acyltransferase activitydefinition[GO:0003988]  
  • IEAEC 2 GO
Palmitoyl-CoA oxidase activitydefinition[GO:0016401]  
1
  • IMPUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Bile acid metabolic processdefinition[GO:0008206]  
1
  • IMPUniProtKB
Fatty acid beta-oxidationdefinition[GO:0006635]  
2
  • IMPUniProtKB
Very long-chain fatty acid metabolic processdefinition[GO:0000038]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.16: Acyl-CoA + acetyl-CoA CoA + 3-oxoacyl-CoA.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Biosynthesis of unsaturated fatty acids  hsa01040+30  
Fatty acid metabolism  hsa00071+30  
Metabolic pathways  hsa01100+30  
Peroxisome  hsa04146+30  
PPAR signaling pathway  hsa03320+30  
Valine, leucine and isoleucine degradation  hsa00280+30  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACAA1
GenomeRNAi: 30
PRO: PR:P09110