MMP10 - Stromelysin-2 - human protein (Function)
 
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MMP10 »  Stromelysin-2   [ EC 3.4.24.22 ]  (SL-2)
 
Protein also known as:  Matrix metalloproteinase-10 (MMP-10).
Gene name:  MMP10
Family name: Peptidase M10A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.  
1
  • UniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
1
  • InterPro 2 GO
Metalloendopeptidase activitydefinition[GO:0004222] silver  
1
  • InterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Proteolysisdefinition[GO:0006508]  
1
  • UniProtKB KW
Regulation of cell migrationdefinition[GO:0030334] silver  
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  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.22: Similar to stromelysin 1, but action on collagen types III, IV and V is weak.  
2
  • UniProtKB
It requires the following cofactors
 Zn(2+) : Binds 2 Zn(2+) ions per subunit.  
2
  • UniProtKB
 Ca(2+)  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Activation of Matrix Metalloproteinases  REACT_118682  
Collagen degradation  REACT_150401  
Degradation of the extracellular matrix  REACT_118572  
 

Keywords

Biological process 
Collagen degradation  definition   [KW-0177]
Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MMP10
GenomeRNAi: 4319
PRO: PR:P09238
Chemistry
GuidetoPHARMACOLOGY: 1634