CXCL1 - Growth-regulated alpha protein - human protein (Function)
 
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CXCL1 »  Growth-regulated alpha protein
 
Protein also known as:  Melanoma growth stimulatory activity (MGSA). Cleaved into:  GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73).
Gene name:  CXCL1
Entry whose protein(s) existence is based on evidence at protein level
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1 118 1
GENE REF ISO

Function

 show evidences
Overview 
Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.  
2
  • UniProtKB
GO molecular function 
Chemokine activitydefinition[GO:0008009] silver  
1
  • InterPro 2 GO
CXCR chemokine receptor bindingdefinition[GO:0045236]  
1
  • RefGenome
Enzyme activator activitydefinition[GO:0008047]  
1
  • PINC
Growth factor activitydefinition[GO:0008083]  
1
  • UniProtKB KW
Receptor bindingdefinition[GO:0005102]  
2
  • PINC
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036]  
1
  • PINC
Cell chemotaxisdefinition[GO:0060326]  
2
  • GOC
  • InterPro 2 GO
Cell proliferationdefinition[GO:0008283]  
1
  • PINC
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
1
  • RefGenome
Chemotaxisdefinition[GO:0006935]  
1
  • PINC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • PINC
Immune responsedefinition[GO:0006955]  
1
  • RefGenome
Inflammatory responsedefinition[GO:0006954]  
1
  • UniProtKB KW
Intracellular signal transductiondefinition[GO:0035556]  
1
  • PINC
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • PINC
Nervous system developmentdefinition[GO:0007399]  
1
  • PINC
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • GOC
Positive regulation of leukocyte chemotaxisdefinition[GO:0002690]  
1
  • RefGenome
Response to lipopolysaccharidedefinition[GO:0032496]  
1
  • RefGenome
Signal transductiondefinition[GO:0007165]  
2
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+2919  
Chemokine signaling pathway  hsa04062+2919  
Cytokine-cytokine receptor interaction  hsa04060+2919  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+2919  
Legionellosis  hsa05134+2919  
NOD-like receptor signaling pathway  hsa04621+2919  
Rheumatoid arthritis  hsa05323+2919  
Salmonella infection  hsa05132+2919  
According to Reactome, this protein belongs to the following pathways:
Chemokine receptors bind chemokines  REACT_15344  
G alpha (i) signalling events  REACT_19231  
 

Keywords

Biological process 
Inflammatory response  definition   [KW-0395]
Molecular function 
Cytokine  definition   [KW-0202]
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CXCL1
GenomeRNAi: 2919
PRO: PR:P09341