LGALS1 - Galectin-1 - human protein (Function)
 
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LGALS1 »  Galectin-1  (Gal-1)
 
Protein also known as:  Beta-galactoside-binding lectin L-14-I.
Gene name:  LGALS1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.  
3
  • CuratedUniProtKB
GO molecular function 
Galactoside bindingdefinition[GO:0016936] silver  
  • IEAInterPro 2 GO
Glycoprotein bindingdefinition[GO:0001948] silver  
  • IEAOrtholog Compara
Lactose bindingdefinition[GO:0030395] silver  
  • IEAOrtholog Compara
Laminin bindingdefinition[GO:0043236] silver  
  • IEAOrtholog Compara
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Signal transducer activitydefinition[GO:0004871]  
1
  • IMPUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
  • IEAOrtholog Compara
Cellular response to organic cyclic compounddefinition[GO:0071407] silver  
  • IEAOrtholog Compara
Multicellular organismal response to stressdefinition[GO:0033555] silver  
  • IEAOrtholog Compara
Myoblast differentiationdefinition[GO:0045445] silver  
  • IEAOrtholog Compara
Negative regulation of cell-substrate adhesiondefinition[GO:0010812] silver  
  • IEAOrtholog Compara
Negative regulation of neuron projection developmentdefinition[GO:0010977] silver  
  • IEAOrtholog Compara
Plasma cell differentiationdefinition[GO:0002317] silver  
  • IEAOrtholog Compara
Positive regulation of erythrocyte aggregationdefinition[GO:0034120] silver  
  • IEAOrtholog Compara
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IMPUniProtKB
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • TASUniProtKB
Response to axon injurydefinition[GO:0048678] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • IMPGOC
T cell costimulationdefinition[GO:0031295] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Galectin-1
GeneWiki: LGALS1
GenomeRNAi: 3956
PRO: PR:P09382