TPM1 - Tropomyosin alpha-1 chain - human protein (Function)
 
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Protein
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TPM1 »  Tropomyosin alpha-1 chain
 
Protein also known as:  Alpha-tropomyosin.
Gene name:  TPM1
Family name: Tropomyosin
Entry whose protein(s) existence is based on evidence at protein level
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1 93 10
GENE REF ISO

Function

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Overview 
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.  
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • TASBHF-UCL
Cytoskeletal protein bindingdefinition[GO:0008092]  
1
  • IPIUniProtKB
Structural constituent of cytoskeletondefinition[GO:0005200]  
1
  • TASBHF-UCL
Structural constituent of muscledefinition[GO:0008307]  
1
  • TASPINC
GO biological process 
Cardiac muscle contractiondefinition[GO:0060048]  
1
  • IMPBHF-UCL
Cellular component movementdefinition[GO:0006928]  
1
  • TASUniProtKB
Cellular response to reactive oxygen speciesdefinition[GO:0034614]  
1
  • IEPBHF-UCL
Cytoskeleton organizationdefinition[GO:0007010]  
1
  • TASBHF-UCL
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Muscle filament slidingdefinition[GO:0030049]  
1
  • ISSBHF-UCL
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • ISSBHF-UCL
Positive regulation of ATPase activitydefinition[GO:0032781]  
1
  • ISSBHF-UCL
Positive regulation of cell adhesiondefinition[GO:0045785]  
1
  • ISSBHF-UCL
Positive regulation of heart rate by epinephrinedefinition[GO:0003065]  
1
  • ISSBHF-UCL
Positive regulation of stress fiber assemblydefinition[GO:0051496]  
1
  • ISSBHF-UCL
Regulation of heart contractiondefinition[GO:0008016]  
1
  • TASPINC
Regulation of muscle contractiondefinition[GO:0006937]  
1
  • TASPINC
Ruffle organizationdefinition[GO:0031529]  
1
  • ISSBHF-UCL
Sarcomere organizationdefinition[GO:0045214]  
1
  • IMPBHF-UCL
Ventricular cardiac muscle tissue morphogenesisdefinition[GO:0055010]  
1
  • IMPBHF-UCL
Wound healingdefinition[GO:0042060]  
1
  • ISSBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cardiac muscle contraction  hsa04260+7168  
Dilated cardiomyopathy  hsa05414+7168  
Hypertrophic cardiomyopathy (HCM)  hsa05410+7168  
According to Reactome, this protein belongs to the following pathways:
Smooth Muscle Contraction  REACT_20558  
Striated Muscle Contraction  REACT_16969  
 

Keywords

Molecular function 
Muscle protein  definition   [KW-0514]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TPM1
GenomeRNAi: 7168
PRO: PR:P09493