WNT2 - Protein Wnt-2 - human protein (Function)
 
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WNT2 »  Protein Wnt-2
 
Gene name:  WNT2
Family name: Wnt
Entry whose protein(s) existence is based on evidence at protein level
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1 68 1
GENE REF ISO

Function

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Overview 
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.  
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
1
  • IDABHF-UCL
Frizzled bindingdefinition[GO:0005109]  
2
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
Receptor agonist activitydefinition[GO:0048018]  
1
  • ICBHF-UCL
GO biological process 
Atrial cardiac muscle tissue morphogenesisdefinition[GO:0055009] silver  
  • IEAOrtholog Compara
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
1
  • IDABHF-UCL
Cardiac epithelial to mesenchymal transitiondefinition[GO:0060317] silver  
  • IEAOrtholog Compara
Cell fate commitmentdefinition[GO:0045165] silver  
  • IBARefGenome
Cell-cell signalingdefinition[GO:0007267]  
1
  • IDABHF-UCL
Cellular response to retinoic aciddefinition[GO:0071300]  
  • ISSOrtholog Curator
Cellular response to transforming growth factor beta stimulusdefinition[GO:0071560]  
1
  • IEPUniProtKB
Iris morphogenesisdefinition[GO:0061072]  
1
  • ISSBHF-UCL
Labyrinthine layer blood vessel developmentdefinition[GO:0060716] silver  
  • IEAOrtholog Compara
Lens development in camera-type eyedefinition[GO:0002088]  
1
  • ISSBHF-UCL
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Lung inductiondefinition[GO:0060492] silver  
  • IEAOrtholog Compara
Mammary gland epithelium developmentdefinition[GO:0061180]  
1
  • IEPUniProtKB
Neuron differentiationdefinition[GO:0030182]  
  • ISSOrtholog Curator
  • IBARefGenome
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
1
  • IMPUniProtKB
Positive regulation of cardiac muscle cell proliferationdefinition[GO:0060045] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IDABHF-UCL
Positive regulation of endothelial cell proliferationdefinition[GO:0001938] silver  
  • IEAOrtholog Compara
Positive regulation of epithelial cell proliferation involved in lung morphogenesisdefinition[GO:0060501] silver  
  • IEAOrtholog Compara
Positive regulation of fibroblast proliferationdefinition[GO:0048146]  
1
  • IMPBHF-UCL
Positive regulation of mesenchymal cell proliferationdefinition[GO:0002053] silver  
  • IEAOrtholog Compara
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Wnt signaling pathwaydefinition[GO:0016055]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+7472  
Hedgehog signaling pathway  hsa04340+7472  
HTLV-I infection  hsa05166+7472  
Melanogenesis  hsa04916+7472  
Pathways in cancer  hsa05200+7472  
Wnt signaling pathway  hsa04310+7472  
According to Reactome, this protein belongs to the following pathways:
Class B/2 (Secretin family receptors)  REACT_18372  
WNT ligand biogenesis and trafficking  REACT_163710  
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: WNT2
GenomeRNAi: 7472
PRO: PR:P09544