CSF1 - Macrophage colony-stimulating factor 1 - human protein (Function)
 
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CSF1 »  Macrophage colony-stimulating factor 1  (MCSF)
 
Protein also known as:  Lanimostim. Cleaved into:  Processed macrophage colony-stimulating factor 1.
Gene name:  CSF1
Entry whose protein(s) existence is based on evidence at protein level
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1 146 3
GENE REF ISO

Function

 show evidences
Overview 
Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.  
4
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
2
  • IDAMGI
  • IDABHF-UCL
Growth factor activitydefinition[GO:0008083]  
2
  • NASUniProtKB
  • IDABHF-UCL
Macrophage colony-stimulating factor receptor bindingdefinition[GO:0005157]  
2
  • ISSBHF-UCL
  • TASUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDABHF-UCL
GO biological process 
Branching involved in mammary gland duct morphogenesisdefinition[GO:0060444] silver  
  • IEAOrtholog Compara
Cell differentiationdefinition[GO:0030154]  
1
  • NASUniProtKB
Cell proliferationdefinition[GO:0008283]  
1
  • NASUniProtKB
Developmental process involved in reproductiondefinition[GO:0003006]  
1
  • ISSBHF-UCL
Hemopoiesisdefinition[GO:0030097]  
1
  • NASUniProtKB
Homeostasis of number of cells within a tissuedefinition[GO:0048873] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954]  
  • IEAUniProtKB KW
Innate immune responsedefinition[GO:0045087]  
  • IEAUniProtKB KW
Macrophage differentiationdefinition[GO:0030225]  
1
  • TASUniProtKB
Mammary duct terminal end bud growthdefinition[GO:0060763] silver  
  • IEAOrtholog Compara
Mammary gland fat developmentdefinition[GO:0060611] silver  
  • IEAOrtholog Compara
Monocyte activationdefinition[GO:0042117]  
1
  • NASBHF-UCL
Odontogenesisdefinition[GO:0042476] silver  
  • IEAOrtholog Compara
Ossificationdefinition[GO:0001503] silver  
  • IEAOrtholog Compara
Osteoclast differentiationdefinition[GO:0030316]  
1
  • IDABHF-UCL
Osteoclast proliferationdefinition[GO:0002158] silver  
  • IEAOrtholog Compara
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • ISSBHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • IDAMGI
  • TASUniProtKB
Positive regulation of cell-matrix adhesiondefinition[GO:0001954]  
1
  • ISSBHF-UCL
Positive regulation of cellular protein metabolic processdefinition[GO:0032270]  
1
  • IDABHF-UCL
Positive regulation of gene expressiondefinition[GO:0010628]  
2
  • IDABHF-UCL
Positive regulation of macrophage derived foam cell differentiationdefinition[GO:0010744]  
1
  • IDABHF-UCL
Positive regulation of macrophage differentiationdefinition[GO:0045651]  
1
  • IDABHF-UCL
Positive regulation of monocyte differentiationdefinition[GO:0045657]  
1
  • ISSBHF-UCL
Positive regulation of mononuclear cell proliferationdefinition[GO:0032946]  
1
  • IDABHF-UCL
Positive regulation of multicellular organism growthdefinition[GO:0040018] silver  
  • IEAOrtholog Compara
Positive regulation of odontogenesis of dentin-containing toothdefinition[GO:0042488] silver  
  • IEAOrtholog Compara
Positive regulation of osteoclast differentiationdefinition[GO:0045672]  
1
  • IDABHF-UCL
Positive regulation of protein kinase activitydefinition[GO:0045860]  
1
  • ISSBHF-UCL
Positive regulation of Ras protein signal transductiondefinition[GO:0046579] silver  
  • IEAOrtholog Compara
Regulation of macrophage derived foam cell differentiationdefinition[GO:0010743]  
1
  • NASBHF-UCL
Regulation of ossificationdefinition[GO:0030278] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+1435  
Hematopoietic cell lineage  hsa04640+1435  
Osteoclast differentiation  hsa04380+1435  
Rheumatoid arthritis  hsa05323+1435  
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Inflammatory response  definition   [KW-0395]
Innate immunity  definition   [KW-0399]
Molecular function 
Cytokine  definition   [KW-0202]
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links