PDGFRB - Platelet-derived growth factor receptor beta - human protein (Function)
 
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PDGFRB »  Platelet-derived growth factor receptor beta   [ EC 2.7.10.1 ]  (PDGFR-beta)
 
Protein also known as:  Beta-type platelet-derived growth factor receptor; CD antigen CD140b.
Gene name:  PDGFRB
Entry whose protein(s) existence is based on evidence at protein level
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1 325 2
GENE REF ISO

Function

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Overview 
Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.  
20
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Phosphatidylinositol 3-kinase bindingdefinition[GO:0043548] silver  
1
  • Ortholog Compara
Platelet activating factor receptor activitydefinition[GO:0004992]  
1
  • PINC
Platelet-derived growth factor beta-receptor activitydefinition[GO:0005019]  
4
  • UniProtKB
  • BHF-UCL
Platelet-derived growth factor bindingdefinition[GO:0048407]  
3
  • UniProtKB
  • BHF-UCL
Platelet-derived growth factor receptor bindingdefinition[GO:0005161]  
1
  • BHF-UCL
Platelet-derived growth factor-activated receptor activitydefinition[GO:0005017]  
1
  • PINC
Protein bindingdefinition[GO:0005515]  
52
  • IntAct
  • UniProtKB
  • BHF-UCL
Protein kinase bindingdefinition[GO:0019901]  
1
  • UniProtKB
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • UniProtKB
Vascular endothelial growth factor bindingdefinition[GO:0038085]  
1
  • BHF-UCL
GO biological process 
Adrenal gland developmentdefinition[GO:0030325] silver  
1
  • Ortholog Compara
Aorta morphogenesisdefinition[GO:0035909]  
1
  • Ortholog Curator
Cardiac myofibril assemblydefinition[GO:0055003]  
1
  • Ortholog Curator
Cell chemotaxisdefinition[GO:0060326]  
2
  • BHF-UCL
  • UniProtKB
Cell migrationdefinition[GO:0016477]  
1
  • UniProtKB
Cell migration involved in coronary angiogenesisdefinition[GO:0060981]  
1
  • Ortholog Curator
Cell migration involved in vasculogenesisdefinition[GO:0035441]  
1
  • Ortholog Curator
Cellular response to platelet-derived growth factor stimulusdefinition[GO:0036120]  
1
  • GOC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • GOC
Glycosaminoglycan biosynthetic processdefinition[GO:0006024] silver  
1
  • Ortholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Inner ear developmentdefinition[GO:0048839] silver  
1
  • Ortholog Compara
Metanephric comma-shaped body morphogenesisdefinition[GO:0072278] silver  
1
  • Ortholog Compara
Metanephric glomerular capillary formationdefinition[GO:0072277]  
1
  • Ortholog Curator
Metanephric glomerular mesangial cell proliferation involved in metanephros developmentdefinition[GO:0072262]  
1
  • Ortholog Curator
Metanephric mesenchymal cell migrationdefinition[GO:0035789] silver  
1
  • Ortholog Compara
Metanephric mesenchyme developmentdefinition[GO:0072075] silver  
1
  • Ortholog Compara
Metanephric S-shaped body morphogenesisdefinition[GO:0072284] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
1
  • Ortholog Compara
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
3
  • UniProtKB
  • BHF-UCL
Phosphatidylinositol metabolic processdefinition[GO:0046488]  
1
  • UniProtKB
Phosphatidylinositol-mediated signalingdefinition[GO:0048015]  
1
  • UniProtKB
Platelet-derived growth factor receptor signaling pathwaydefinition[GO:0048008]  
2
  • UniProtKB
  • BHF-UCL
Platelet-derived growth factor receptor-beta signaling pathwaydefinition[GO:0035791]  
1
  • UniProtKB
Positive regulation of calcium ion importdefinition[GO:0090280]  
1
  • Ortholog Curator
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • BHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • UniProtKB
Positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwaydefinition[GO:0038091]  
1
  • BHF-UCL
Positive regulation of chemotaxisdefinition[GO:0050921]  
1
  • Ortholog Curator
Positive regulation of collagen biosynthetic processdefinition[GO:0032967] silver  
1
  • Ortholog Compara
Positive regulation of DNA biosynthetic processdefinition[GO:2000573]  
1
  • Ortholog Curator
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
2
  • UniProtKB
  • Ortholog Curator
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
1
  • Ortholog Curator
Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwaydefinition[GO:0035793]  
1
  • Ortholog Curator
Positive regulation of mitosisdefinition[GO:0045840]  
1
  • Ortholog Curator
Positive regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043552]  
1
  • UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068]  
1
  • Ortholog Curator
Positive regulation of phospholipase C activitydefinition[GO:0010863]  
1
  • UniProtKB
Positive regulation of phosphoprotein phosphatase activitydefinition[GO:0032516]  
1
  • UniProtKB
Positive regulation of reactive oxygen species metabolic processdefinition[GO:2000379]  
1
  • Ortholog Curator
Positive regulation of smooth muscle cell migrationdefinition[GO:0014911]  
3
  • UniProtKB
  • Ortholog Curator
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
2
  • UniProtKB
  • Ortholog Curator
Protein autophosphorylationdefinition[GO:0046777]  
3
  • UniProtKB
  • BHF-UCL
Regulation of actin cytoskeleton organizationdefinition[GO:0032956]  
1
  • Ortholog Curator
Regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050730] silver  
1
  • Ortholog Compara
Response to estradioldefinition[GO:0032355] silver  
1
  • Ortholog Compara
Response to fluid shear stressdefinition[GO:0034405] silver  
1
  • Ortholog Compara
Response to hydrogen peroxidedefinition[GO:0042542] silver  
1
  • Ortholog Compara
Response to hyperoxiadefinition[GO:0055093] silver  
1
  • Ortholog Compara
Response to retinoic aciddefinition[GO:0032526] silver  
1
  • Ortholog Compara
Response to toxic substancedefinition[GO:0009636] silver  
1
  • Ortholog Compara
Retina vasculature development in camera-type eyedefinition[GO:0061298]  
1
  • Ortholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • UniProtKB
Skeletal system morphogenesisdefinition[GO:0048705] silver  
1
  • Ortholog Compara
Smooth muscle cell chemotaxisdefinition[GO:0071670]  
1
  • Ortholog Curator
Smooth muscle tissue developmentdefinition[GO:0048745] silver  
1
  • Ortholog Compara
Tissue homeostasisdefinition[GO:0001894] silver  
1
  • Ortholog Compara
Wound healingdefinition[GO:0042060] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
5
  • UniProtKB
  • PROSITE-ProRule
It is regulated in the following manner
Present in an inactive conformation in the absence of bound ligand. Binding of PDGFB and/or PDGFD leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by imatinib.  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+5159  
Cytokine-cytokine receptor interaction  hsa04060+5159  
Focal adhesion  hsa04510+5159  
Gap junction  hsa04540+5159  
Glioma  hsa05214+5159  
HTLV-I infection  hsa05166+5159  
MAPK signaling pathway  hsa04010+5159  
Melanoma  hsa05218+5159  
Pathways in cancer  hsa05200+5159  
Prostate cancer  hsa05215+5159  
Regulation of actin cytoskeleton  hsa04810+5159  
According to Reactome, this protein belongs to the following pathways:
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
Downstream signal transduction  REACT_17025  
PIP3 activates AKT signaling  REACT_75829  
Signaling by PDGF  REACT_16888  
 

Keywords

Biological process 
Chemotaxis  definition   [KW-0145]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PDGFRB
GenomeRNAi: 5159
PRO: PR:P09619
Chemistry
GuidetoPHARMACOLOGY: 1804