PDGFRB - Platelet-derived growth factor receptor beta - human protein (Function)
 
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PDGFRB »  Platelet-derived growth factor receptor beta   [ EC 2.7.10.1 ]  (PDGFR-beta)
 
Protein also known as:  Beta-type platelet-derived growth factor receptor; CD antigen CD140b.
Gene name:  PDGFRB
Entry whose protein(s) existence is based on evidence at protein level
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1 307 1
GENE REF ISO

Function

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Overview 
Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.  
19
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Phosphatidylinositol 3-kinase bindingdefinition[GO:0043548] silver  
  • IEAOrtholog Compara
Platelet activating factor receptor activitydefinition[GO:0004992]  
1
  • TASPINC
Platelet-derived growth factor beta-receptor activitydefinition[GO:0005019]  
4
  • IDAUniProtKB
  • IDABHF-UCL
Platelet-derived growth factor bindingdefinition[GO:0048407]  
3
  • IDAUniProtKB
  • IPIBHF-UCL
Platelet-derived growth factor receptor bindingdefinition[GO:0005161]  
1
  • IPIBHF-UCL
Platelet-derived growth factor-activated receptor activitydefinition[GO:0005017]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
49
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • IDAUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
Vascular endothelial growth factor bindingdefinition[GO:0038085]  
1
  • IPIBHF-UCL
GO biological process 
Adrenal gland developmentdefinition[GO:0030325] silver  
  • IEAOrtholog Compara
Aorta morphogenesisdefinition[GO:0035909]  
  • ISSOrtholog Curator
Cardiac myofibril assemblydefinition[GO:0055003]  
  • ISSOrtholog Curator
Cell chemotaxisdefinition[GO:0060326]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Cell migrationdefinition[GO:0016477]  
1
  • IMPUniProtKB
Cell migration involved in coronary angiogenesisdefinition[GO:0060981]  
  • ISSOrtholog Curator
Cell migration involved in vasculogenesisdefinition[GO:0035441]  
  • ISSOrtholog Curator
Cellular response to platelet-derived growth factor stimulusdefinition[GO:0036120]  
1
  • TASGOC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASGOC
Glycosaminoglycan biosynthetic processdefinition[GO:0006024] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Inner ear developmentdefinition[GO:0048839] silver  
  • IEAOrtholog Compara
Metanephric comma-shaped body morphogenesisdefinition[GO:0072278] silver  
  • IEAOrtholog Compara
Metanephric glomerular capillary formationdefinition[GO:0072277]  
  • ISSOrtholog Curator
Metanephric glomerular mesangial cell proliferation involved in metanephros developmentdefinition[GO:0072262]  
  • ISSOrtholog Curator
Metanephric mesenchymal cell migrationdefinition[GO:0035789] silver  
  • IEAOrtholog Compara
Metanephric mesenchyme developmentdefinition[GO:0072075] silver  
  • IEAOrtholog Compara
Metanephric S-shaped body morphogenesisdefinition[GO:0072284] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
3
  • IDAUniProtKB
  • IDABHF-UCL
Phosphatidylinositol metabolic processdefinition[GO:0046488]  
1
  • IMPUniProtKB
Phosphatidylinositol-mediated signalingdefinition[GO:0048015]  
1
  • IMPUniProtKB
Platelet-derived growth factor receptor signaling pathwaydefinition[GO:0048008]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Platelet-derived growth factor receptor-beta signaling pathwaydefinition[GO:0035791]  
1
  • IMPUniProtKB
Positive regulation of calcium ion importdefinition[GO:0090280]  
  • ISSOrtholog Curator
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IDABHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IMPUniProtKB
Positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwaydefinition[GO:0038091]  
1
  • IDABHF-UCL
Positive regulation of chemotaxisdefinition[GO:0050921]  
  • ISSOrtholog Curator
Positive regulation of collagen biosynthetic processdefinition[GO:0032967] silver  
  • IEAOrtholog Compara
Positive regulation of DNA biosynthetic processdefinition[GO:2000573]  
  • ISSOrtholog Curator
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • IMPUniProtKB
  • ISSOrtholog Curator
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
  • ISSOrtholog Curator
Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwaydefinition[GO:0035793]  
  • ISSOrtholog Curator
Positive regulation of mitosisdefinition[GO:0045840]  
  • ISSOrtholog Curator
Positive regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043552]  
1
  • IDAUniProtKB
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068]  
  • ISSOrtholog Curator
Positive regulation of phospholipase C activitydefinition[GO:0010863]  
1
  • IDAUniProtKB
Positive regulation of phosphoprotein phosphatase activitydefinition[GO:0032516]  
1
  • IDAUniProtKB
Positive regulation of reactive oxygen species metabolic processdefinition[GO:2000379]  
  • ISSOrtholog Curator
Positive regulation of smooth muscle cell migrationdefinition[GO:0014911]  
1
  • IMPUniProtKB
  • ISSOrtholog Curator
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
1
  • IMPUniProtKB
  • ISSOrtholog Curator
Protein autophosphorylationdefinition[GO:0046777]  
3
  • IDAUniProtKB
  • IDABHF-UCL
Regulation of actin cytoskeleton organizationdefinition[GO:0032956]  
  • ISSOrtholog Curator
Regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050730] silver  
  • IEAOrtholog Compara
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Response to fluid shear stressdefinition[GO:0034405] silver  
  • IEAOrtholog Compara
Response to hydrogen peroxidedefinition[GO:0042542] silver  
  • IEAOrtholog Compara
Response to hyperoxiadefinition[GO:0055093] silver  
  • IEAOrtholog Compara
Response to retinoic aciddefinition[GO:0032526] silver  
  • IEAOrtholog Compara
Response to toxic substancedefinition[GO:0009636] silver  
  • IEAOrtholog Compara
Retina vasculature development in camera-type eyedefinition[GO:0061298]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • IDAUniProtKB
Skeletal system morphogenesisdefinition[GO:0048705] silver  
  • IEAOrtholog Compara
Smooth muscle cell chemotaxisdefinition[GO:0071670]  
  • ISSOrtholog Curator
Smooth muscle tissue developmentdefinition[GO:0048745] silver  
  • IEAOrtholog Compara
Tissue homeostasisdefinition[GO:0001894] silver  
  • IEAOrtholog Compara
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179] silver  
  • IEAOrtholog Compara
Wound healingdefinition[GO:0042060] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
3
  • CuratedUniProtKB
It is regulated in the following manner
Present in an inactive conformation in the absence of bound ligand. Binding of PDGFB and/or PDGFD leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by imatinib.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+5159  
Cytokine-cytokine receptor interaction  hsa04060+5159  
Focal adhesion  hsa04510+5159  
Gap junction  hsa04540+5159  
Glioma  hsa05214+5159  
HTLV-I infection  hsa05166+5159  
MAPK signaling pathway  hsa04010+5159  
Melanoma  hsa05218+5159  
Pathways in cancer  hsa05200+5159  
Prostate cancer  hsa05215+5159  
Regulation of actin cytoskeleton  hsa04810+5159  
According to Reactome, this protein belongs to the following pathways:
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
Downstream signal transduction  REACT_17025  
PIP3 activates AKT signaling  REACT_75829  
Signaling by PDGF  REACT_16888  
 

Keywords

Biological process 
Chemotaxis  definition   [KW-0145]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PDGFRB
GenomeRNAi: 5159
PRO: PR:P09619
Chemistry
GuidetoPHARMACOLOGY: 1804