DLD - Dihydrolipoyl dehydrogenase, mitochondrial - human protein (Function)
 
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Protein
Gene
References

 
DLD »  Dihydrolipoyl dehydrogenase, mitochondrial   [ EC 1.8.1.4 ]
 
Protein also known as:  Glycine cleavage system L protein.
Gene name:  DLD
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.  
  • CuratedUniProtKB
GO molecular function 
Dihydrolipoyl dehydrogenase activitydefinition[GO:0004148]  
  • IEAEC 2 GO
Flavin adenine dinucleotide bindingdefinition[GO:0050660] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell redox homeostasisdefinition[GO:0045454] silver  
  • IEAInterPro 2 GO
Gastrulationdefinition[GO:0007369] silver  
  • IEAOrtholog Compara
Mitochondrial electron transport, NADH to ubiquinonedefinition[GO:0006120] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508] silver  
  • IEAOrtholog Compara
Regulation of membrane potentialdefinition[GO:0042391] silver  
  • IEAOrtholog Compara
Sperm capacitationdefinition[GO:0048240] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.8.1.4: Protein N(6)-(dihydrolipoyl)lysine + NAD(+) protein N(6)-(lipoyl)lysine + NADH.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 FAD per subunit (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Citrate cycle (TCA cycle)  hsa00020+1738  
Glycine, serine and threonine metabolism  hsa00260+1738  
Glycolysis / Gluconeogenesis  hsa00010+1738  
Metabolic pathways  hsa01100+1738  
Pyruvate metabolism  hsa00620+1738  
Valine, leucine and isoleucine degradation  hsa00280+1738  
According to Reactome, this protein belongs to the following pathways:
Branched-chain amino acid catabolism  REACT_197  
Citric acid cycle (TCA cycle)  REACT_1785  
Lysine catabolism  REACT_1298  
Pyruvate metabolism  REACT_2071  
Regulation of pyruvate dehydrogenase (PDH) complex  REACT_12528  
 
More information is available from:
Note 
The active site is a redox-active disulfide bond.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P09622
Other
GeneWiki: Dihydrolipoamide_dehydrogenase
GenomeRNAi: 1738
PRO: PR:P09622