CTSH - Pro-cathepsin H - human protein (Function)
 
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CTSH »  Pro-cathepsin H
 
Cleaved into:  Cathepsin H; Cathepsin H heavy chain; Cathepsin H light chain; Cathepsin H mini chain.
Gene name:  CTSH
Family name: Peptidase C1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Important for the overall degradation of proteins in lysosomes.  
1
  • UniProtKB
GO molecular function 
Aminopeptidase activitydefinition[GO:0004177]  
1
  • UniProtKB
Cysteine-type endopeptidase activator activity involved in apoptotic processdefinition[GO:0008656]  
1
  • UniProtKB
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
2
  • UniProtKB
  • BHF-UCL
Cysteine-type peptidase activitydefinition[GO:0008234]  
1
  • UniProtKB
Endopeptidase activitydefinition[GO:0004175]  
2
  • UniProtKB
HLA-A specific activating MHC class I receptor activitydefinition[GO:0030108]  
1
  • UniProtKB
Kininogen bindingdefinition[GO:0030984] silver  
1
  • Ortholog Compara
Peptidase activitydefinition[GO:0008233]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
Protein self-associationdefinition[GO:0043621] silver  
1
  • Ortholog Compara
Serine-type endopeptidase activitydefinition[GO:0004252]  
1
  • Ortholog Curator
Thyroid hormone bindingdefinition[GO:0070324]  
1
  • UniProtKB
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
2
  • GOC
  • Ortholog Compara
Adaptive immune responsedefinition[GO:0002250]  
1
  • UniProtKB
Antigen processing and presentationdefinition[GO:0019882]  
1
  • UniProtKB
Bradykinin catabolic processdefinition[GO:0010815]  
1
  • UniProtKB
Cellular response to thyroid hormone stimulusdefinition[GO:0097067]  
1
  • UniProtKB
Dichotomous subdivision of terminal units involved in lung branchingdefinition[GO:0060448]  
1
  • Ortholog Curator
ERK1 and ERK2 cascadedefinition[GO:0070371]  
1
  • UniProtKB
Immune response-regulating signaling pathwaydefinition[GO:0002764]  
1
  • UniProtKB
Membrane protein proteolysisdefinition[GO:0033619]  
1
  • UniProtKB
Metanephros developmentdefinition[GO:0001656]  
1
  • Ortholog Curator
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • Ortholog Curator
Neuropeptide catabolic processdefinition[GO:0010813]  
1
  • UniProtKB
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • Ortholog Curator
Positive regulation of apoptotic signaling pathwaydefinition[GO:2001235] silver  
1
  • Ortholog Compara
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • UniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • Ortholog Curator
Positive regulation of epithelial cell migrationdefinition[GO:0010634]  
1
  • Ortholog Curator
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • UniProtKB
Positive regulation of peptidase activitydefinition[GO:0010952]  
1
  • UniProtKB
Protein destabilizationdefinition[GO:0031648]  
1
  • UniProtKB
Proteolysisdefinition[GO:0006508]  
3
  • UniProtKB
  • BHF-UCL
Response to retinoic aciddefinition[GO:0032526]  
1
  • Ortholog Curator
Spermatogenesisdefinition[GO:0007283] silver  
1
  • Ortholog Compara
Surfactant homeostasisdefinition[GO:0043129]  
1
  • UniProtKB
T cell mediated cytotoxicitydefinition[GO:0001913]  
1
  • Ortholog Curator
Zymogen activationdefinition[GO:0031638]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.16: Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Lysosome  hsa04142+1512  
According to Reactome, this protein belongs to the following pathway:
MHC class II antigen presentation  REACT_121399  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P09668
Other
GeneWiki: Cathepsin_H
GenomeRNAi: 1512
PRO: PR:P09668