ALOX5 - Arachidonate 5-lipoxygenase - human protein (Function)
 
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Protein
Gene
References

 
ALOX5 »  Arachidonate 5-lipoxygenase   [ EC 1.13.11.34 ]  (5-LO)
 
Gene name:  ALOX5
Family name: Lipoxygenase
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.  
1
  • CuratedUniProtKB
GO molecular function 
Arachidonate 5-lipoxygenase activitydefinition[GO:0004051]  
1
  • IDAUniProtKB
Iron ion bindingdefinition[GO:0005506]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
  • IPIIntAct
GO biological process 
Leukotriene biosynthetic processdefinition[GO:0019370]  
1
  • IDAUniProtKB
Leukotriene production involved in inflammatory responsedefinition[GO:0002540] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.13.11.34: Arachidonate + O(2) leukotriene A(4) + H(2)O.  
1
  • CuratedUniProtKB
It requires the following cofactors
Binds 1 iron ion per subunit.  
1
  • CuratedUniProtKB
Binds 2 calcium ions per subunit (By similarity).  
1
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Arachidonic acid metabolism  hsa00590+240  
Metabolic pathways  hsa01100+240  
Toxoplasmosis  hsa05145+240  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Leukotriene biosynthesis  definition   [KW-0434]
Molecular function 
Dioxygenase  definition   [KW-0223]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Arachidonate_5-lipoxygenase
GenomeRNAi: 240
PRO: PR:P09917
Chemistry
GuidetoPHARMACOLOGY: 1385