ALOX5 - Arachidonate 5-lipoxygenase - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
ALOX5 »  Arachidonate 5-lipoxygenase   [ EC 1.13.11.34 ]  (5-LO)
 
Gene name:  ALOX5
Family name: Lipoxygenase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 169 5
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.  
2
  • UniProtKB
GO molecular function 
Arachidonate 5-lipoxygenase activitydefinition[GO:0004051]  
1
  • UniProtKB
Iron ion bindingdefinition[GO:0005506]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
GO biological process 
Leukotriene biosynthetic processdefinition[GO:0019370]  
1
  • UniProtKB
Leukotriene production involved in inflammatory responsedefinition[GO:0002540] silver  
1
  • Ortholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
1
  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.13.11.34: Arachidonate + O(2) leukotriene A(4) + H(2)O.  
2
  • UniProtKB
It requires the following cofactors
 Fe cation : Binds 1 Fe cation per subunit.  
3
  • UniProtKB
  • PROSITE-ProRule
 Ca(2+) : Binds 2 calcium ions per subunit.  
1
  • UniProtKB
Pathways 
This protein is involved in the following pathway
Lipid metabolism; leukotriene A4 biosynthesis  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Arachidonic acid metabolism  hsa00590+240  
Metabolic pathways  hsa01100+240  
Toxoplasmosis  hsa05145+240  
According to Reactome, this protein belongs to the following pathways:
Synthesis of 5-eicosatetraenoic acids  REACT_150209  
Synthesis of Leukotrienes (LT) and Eoxins (EX)  REACT_150420  
Synthesis of Lipoxins (LX)  REACT_150320  
 
More information is available from:
 

Keywords

Biological process 
Leukotriene biosynthesis  definition   [KW-0434]
Molecular function 
Dioxygenase  definition   [KW-0223]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Arachidonate_5-lipoxygenase
GenomeRNAi: 240
PRO: PR:P09917
Chemistry
GuidetoPHARMACOLOGY: 1385