CSF3 - Granulocyte colony-stimulating factor - human protein (Function)
 
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CSF3 »  Granulocyte colony-stimulating factor  (G-CSF)
 
Protein also known as:  Pluripoietin; International Nonproprietary Name Filgrastim.
Gene name:  CSF3
Family name: IL-6
Entry whose protein(s) existence is based on evidence at protein level
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1 124 3
GENE REF ISO

Function

 show evidences
Overview 
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.  
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
2
  • IDABHF-UCL
  • NASUniProtKB
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Granulocyte colony-stimulating factor receptor bindingdefinition[GO:0005130]  
1
  • TASPINC
Growth factor activitydefinition[GO:0008083] silver  
  • IEAOrtholog Compara
GO biological process 
Cellular response to cytokine stimulusdefinition[GO:0071345]  
1
  • IDABHF-UCL
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
  • IEAOrtholog Compara
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • NASUniProtKB
Granulocyte differentiationdefinition[GO:0030851]  
1
  • NASUniProtKB
Immune responsedefinition[GO:0006955] silver  
  • IEAInterPro 2 GO
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Negative regulation of neuron deathdefinition[GO:1901215] silver  
  • IEAOrtholog Compara
Positive regulation of actin cytoskeleton reorganizationdefinition[GO:2000251]  
1
  • IDABHF-UCL
Positive regulation of actin filament polymerizationdefinition[GO:0030838]  
1
  • IDABHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138]  
1
  • IDABHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
1
  • IDABHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068]  
1
  • IDABHF-UCL
Positive regulation of protein bindingdefinition[GO:0032092]  
1
  • IDABHF-UCL
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
1
  • IDABHF-UCL
Positive regulation of transcription factor import into nucleusdefinition[GO:0042993]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+1440  
Hematopoietic cell lineage  hsa04640+1440  
Jak-STAT signaling pathway  hsa04630+1440  
Malaria  hsa05144+1440  
Caution 
PubMed2420009 misquotes the gene name as "CSF1".  
1
  • CuratedUniProtKB
 

Keywords

Molecular function 
Cytokine  definition   [KW-0202]
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links