ALPI - Intestinal-type alkaline phosphatase - human protein (Function)
 
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ALPI »  Intestinal-type alkaline phosphatase   [ EC 3.1.3.1 ]  (IAP)
 
Gene name:  ALPI
Family name: Alkaline phosphatase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
Alkaline phosphatase activitydefinition[GO:0004035]  
1
  • NASUniProtKB
  • ISSOrtholog Curator
Magnesium ion bindingdefinition[GO:0000287]  
  • ISSOrtholog Curator
Zinc ion bindingdefinition[GO:0008270]  
  • ISSOrtholog Curator
GO biological process 
Dephosphorylationdefinition[GO:0016311]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.1: A phosphate monoester + H(2)O an alcohol + phosphate.  
  • CuratedUniProtKB
It requires the following cofactors
Binds 1 magnesium ion (By similarity).  
  • CuratedUniProtKB
Binds 2 zinc ions (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Folate biosynthesis  hsa00790+248  
Metabolic pathways  hsa01100+248  
Note 
In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P09923
Other
GeneWiki: ALPI
GenomeRNAi: 248
PRO: PR:P09923