FURIN - Furin - human protein (Function)
 
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FURIN »  Furin   [ EC 3.4.21.75 ]
 
Protein also known as:  Paired basic amino acid residue-cleaving enzyme (PACE).
Gene name:  FURIN
Family name: Peptidase S8 » Furin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 126 1
GENE REF ISO

Function

 show evidences
Overview 
Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.  
1
  • CuratedUniProtKB
GO molecular function 
Endopeptidase activitydefinition[GO:0004175]  
2
  • IDABHF-UCL
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Nerve growth factor bindingdefinition[GO:0048406]  
1
  • IDABHF-UCL
Peptidase activitydefinition[GO:0008233]  
3
  • IDAMGI
  • IDAUniProtKB
Peptide bindingdefinition[GO:0042277]  
1
  • IDABHF-UCL
Protease bindingdefinition[GO:0002020]  
1
  • IPIBHF-UCL
Serine-type endopeptidase activitydefinition[GO:0004252]  
2
  • IDABHF-UCL
Serine-type endopeptidase inhibitor activitydefinition[GO:0004867]  
1
  • IDABHF-UCL
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • IMPBHF-UCL
Negative regulation of endopeptidase activitydefinition[GO:0010951]  
1
  • IDAGOC
Negative regulation of low-density lipoprotein particle receptor catabolic processdefinition[GO:0032804]  
1
  • IDAHGNC
Not  Negative regulation of nerve growth factor productiondefinition[GO:0032904]  
1
  • IDABHF-UCL
Negative regulation of transforming growth factor beta1 productiondefinition[GO:0032911]  
1
  • IMPBHF-UCL
Nerve growth factor productiondefinition[GO:0032902]  
1
  • IDABHF-UCL
Peptide biosynthetic processdefinition[GO:0043043]  
1
  • IDABHF-UCL
Peptide hormone processingdefinition[GO:0016486]  
1
  • IDABHF-UCL
Positive regulation of membrane protein ectodomain proteolysisdefinition[GO:0051044]  
1
  • ICBHF-UCL
Protein processingdefinition[GO:0016485]  
6
  • IMPBHF-UCL
  • IDAMGI
  • IDAUniProtKB
Regulation of endopeptidase activitydefinition[GO:0052548]  
1
  • IDABHF-UCL
Regulation of protein catabolic processdefinition[GO:0042176]  
1
  • IMPBHF-UCL
Regulation of signal transductiondefinition[GO:0009966] silver  
  • IEAOrtholog Compara
Secretion by celldefinition[GO:0032940]  
1
  • IDABHF-UCL
Signal peptide processingdefinition[GO:0006465]  
1
  • IDAHGNC
Viral life cycledefinition[GO:0019058]  
1
  • IEPBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.75: Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and vWF from their respective precursors.  
  • CuratedUniProtKB
It requires the following cofactor
Calcium.  
  • CuratedUniProtKB
It is regulated in the following manner
Could be inhibited by the not secondly cleaved propeptide.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Influenza A  hsa05164+5045  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Disease  REACT_116125  
Extracellular matrix organization  REACT_118779  
Metabolism of proteins  REACT_17015  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Furin
GenomeRNAi: 5045
PRO: PR:P09958
Chemistry
GuidetoPHARMACOLOGY: 2366