FURIN - Furin - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
FURIN »  Furin   [ EC 3.4.21.75 ]
 
Protein also known as:  Paired basic amino acid residue-cleaving enzyme (PACE).
Gene name:  FURIN
Family name: Peptidase S8 » Furin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 161 1
GENE REF ISO

Function

 show evidences
Overview 
Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.  
2
  • UniProtKB
GO molecular function 
Endopeptidase activitydefinition[GO:0004175]  
2
  • BHF-UCL
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Nerve growth factor bindingdefinition[GO:0048406]  
1
  • BHF-UCL
Peptidase activitydefinition[GO:0008233]  
4
  • BHF-UCL
  • MGI
  • UniProtKB
Peptide bindingdefinition[GO:0042277]  
1
  • BHF-UCL
Protease bindingdefinition[GO:0002020]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Serine-type endopeptidase activitydefinition[GO:0004252]  
2
  • BHF-UCL
Serine-type endopeptidase inhibitor activitydefinition[GO:0004867]  
1
  • BHF-UCL
GO biological process 
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Cell proliferationdefinition[GO:0008283]  
1
  • BHF-UCL
Negative regulation of endopeptidase activitydefinition[GO:0010951]  
1
  • GOC
Negative regulation of low-density lipoprotein particle receptor catabolic processdefinition[GO:0032804]  
1
  • HGNC
Not  Negative regulation of nerve growth factor productiondefinition[GO:0032904]  
1
  • BHF-UCL
Negative regulation of transforming growth factor beta1 productiondefinition[GO:0032911]  
1
  • BHF-UCL
Nerve growth factor productiondefinition[GO:0032902]  
1
  • BHF-UCL
Peptide biosynthetic processdefinition[GO:0043043]  
1
  • BHF-UCL
Peptide hormone processingdefinition[GO:0016486]  
1
  • BHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335] silver  
1
  • Ortholog Compara
Positive regulation of membrane protein ectodomain proteolysisdefinition[GO:0051044]  
1
  • BHF-UCL
Positive regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0030511] silver  
1
  • Ortholog Compara
Protein processingdefinition[GO:0016485]  
7
  • BHF-UCL
  • MGI
  • UniProtKB
Regulation of endopeptidase activitydefinition[GO:0052548]  
1
  • BHF-UCL
Regulation of low-density lipoprotein particle receptor biosynthetic processdefinition[GO:0045714] silver  
1
  • Ortholog Compara
Regulation of protein catabolic processdefinition[GO:0042176]  
1
  • BHF-UCL
Secretion by celldefinition[GO:0032940]  
1
  • BHF-UCL
Signal peptide processingdefinition[GO:0006465]  
1
  • HGNC
Viral life cycledefinition[GO:0019058]  
1
  • BHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.75: Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.  
1
  • UniProtKB
It requires the following cofactor
 Ca(2+)  
1
  • UniProtKB
It is regulated in the following manner
Could be inhibited by the not secondly cleaved propeptide.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Influenza A  hsa05164+5045  
According to Reactome, this protein belongs to the following pathways:
Activation of Matrix Metalloproteinases  R-HSA-1592389  
Collagen degradation  R-HSA-1442490  
Elastic fibre formation  R-HSA-1566948  
NGF processing  R-HSA-167060  
Pre-NOTCH Processing in Golgi  R-HSA-1912420  
Removal of aminoterminal propeptides from gamma-carboxylated proteins  R-HSA-159782  
Signaling by NODAL  R-HSA-1181150  
Signaling by PDGF  R-HSA-186797  
Synthesis and processing of ENV and VPU  R-HSA-171286  
TGF-beta receptor signaling activates SMADs  R-HSA-2173789  
Uptake and function of anthrax toxins  R-HSA-5210891  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Furin
GenomeRNAi: 5045
PRO: PR:P09958
Chemistry
GuidetoPHARMACOLOGY: 2366