LTA4H - Leukotriene A-4 hydrolase - human protein (Function)
 
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LTA4H »  Leukotriene A-4 hydrolase   [ EC 3.3.2.6 ]  (LTA-4 hydrolase)
 
Protein also known as:  Leukotriene A(4) hydrolase.
Gene name:  LTA4H
Family name: Peptidase M1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.  
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  • CuratedUniProtKB
GO molecular function 
Aminopeptidase activitydefinition[GO:0004177]  
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  • IDAUniProtKB
Epoxide hydrolase activitydefinition[GO:0004301]  
2
  • IDAUniProtKB
Leukotriene-A4 hydrolase activitydefinition[GO:0004463]  
1
  • IDAUniProtKB
Metallopeptidase activitydefinition[GO:0008237]  
  • IEAUniProtKB KW
Peptidase activitydefinition[GO:0008233]  
1
  • TASPINC
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
2
  • IDAUniProtKB
GO biological process 
Inflammatory responsedefinition[GO:0006954]  
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  • NASPINC
Leukotriene biosynthetic processdefinition[GO:0019370]  
1
  • IDAUniProtKB
Peptide catabolic processdefinition[GO:0043171]  
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  • IDAUniProtKB
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.3.2.6: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.  
6
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit.  
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  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by bestatin. Subject to suicide inhibition by leukotriene A4, due to the formation of a covalent adduct at Tyr-379.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Arachidonic acid metabolism  hsa00590+4048  
Metabolic pathways  hsa01100+4048  
According to Reactome, this protein belongs to the following pathway:
Synthesis of Leukotrienes (LT) and Eoxins (EX)  REACT_150420  
 
More information is available from:
 

Keywords

Biological process 
Leukotriene biosynthesis  definition   [KW-0434]
Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 4048
PRO: PR:P09960
Chemistry
GuidetoPHARMACOLOGY: 1395