ALDOC - Fructose-bisphosphate aldolase C - human protein (Function)
 
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Protein
Gene
References

 
ALDOC »  Fructose-bisphosphate aldolase C   [ EC 4.1.2.13 ]
 
Protein also known as:  Brain-type aldolase.
Gene name:  ALDOC
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
Cytoskeletal protein bindingdefinition[GO:0008092]  
1
  • IDABHF-UCL
Fructose-bisphosphate aldolase activitydefinition[GO:0004332]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Apoptotic processdefinition[GO:0006915] silver  
  • IEAOrtholog Compara
Epithelial cell differentiationdefinition[GO:0030855]  
1
  • IEPUniProtKB
Fructose 1,6-bisphosphate metabolic processdefinition[GO:0030388]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Fructose metabolic processdefinition[GO:0006000]  
1
  • TASPINC
Glycolytic processdefinition[GO:0006096]  
  • IEAUniPathway
Organ regenerationdefinition[GO:0031100] silver  
  • IEAOrtholog Compara
Protein heterotetramerizationdefinition[GO:0051290] silver  
  • IEAOrtholog Compara
Protein homotetramerizationdefinition[GO:0051289] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to organic cyclic compounddefinition[GO:0014070] silver  
  • IEAOrtholog Compara
Response to organonitrogen compounddefinition[GO:0010243] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.1.2.13: D-fructose 1,6-bisphosphate glycerone phosphate + D-glyceraldehyde 3-phosphate.  
1
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Fructose and mannose metabolism  hsa00051+230  
Glycolysis / Gluconeogenesis  hsa00010+230  
Metabolic pathways  hsa01100+230  
Pentose phosphate pathway  hsa00030+230  
According to Reactome, this protein belongs to the following pathways:
Gluconeogenesis  REACT_1520  
Glycolysis  REACT_1383  
 
More information is available from:
Note 
In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.  
  • CuratedUniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 10.7 uM for fructose 1,6-bisphosphate
KM 16 mM for fructose 1-phosphate

Keywords

Biological process 
Glycolysis  definition   [KW-0324]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P09972
Other
GeneWiki: Aldolase_C
GenomeRNAi: 230
PRO: PR:P09972