HIST1H2AI - Histone H2A type 1 - human protein (Function)
 
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Protein
Gene
References

 
HIST1H2AG »  Histone H2A type 1  (H2A.1)
 
Protein also known as:  Histone H2A/p.
Gene name:  HIST1H2AG ; HIST1H2AI ; HIST1H2AK ; HIST1H2AL ; HIST1H2AM
Family name: Histone H2A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
5 57 1
GENE REF ISO

Function

 show evidences
Overview 
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAInterPro 2 GO
GO biological process 
Nucleosome assemblydefinition[GO:0006334] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Systemic lupus erythematosus  hsa05322+8969  
Systemic lupus erythematosus  hsa05322+8330  
Systemic lupus erythematosus  hsa05322+8336  
Systemic lupus erythematosus  hsa05322+8332  
Systemic lupus erythematosus  hsa05322+8329  
According to Reactome, this protein belongs to the following pathway:
Chromatin organization  REACT_172623  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HIST1H2AL
GeneWiki: HIST1H2AI
GeneWiki: HIST1H2AG
GeneWiki: HIST1H2AK
GeneWiki: HIST1H2AM
PRO: PR:P0C0S8