CFC1 - Cryptic protein - human protein (Function)
 
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Protein
Gene
References

 
CFC1 »  Cryptic protein
 
Protein also known as:  Cryptic family protein 1.
Gene name:  CFC1
Entry whose protein(s) existence is based on evidence at protein level
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1 13 1
GENE REF ISO

Function

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Overview 
NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation.  
1
  • CuratedUniProtKB
GO molecular function 
Nodal bindingdefinition[GO:0038100]  
1
  • IPIUniProtKB
GO biological process 
Determination of left/right symmetrydefinition[GO:0007368]  
1
  • NASUniProtKB
Gastrulationdefinition[GO:0007369]  
  • IEAUniProtKB KW
Nodal signaling pathwaydefinition[GO:0038092]  
1
  • IMPUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Developmental Biology  REACT_111045  
Caution 
This gene differs from CFC1B by only one residue at position 78:R -> W. R78W is also thought to be a CFC1 polymorphism which has been shown to lead to a different cell surface distribution and activity (PubMed11799476 and PubMed11062482).  
2
  • CuratedUniProtKB
 

Keywords

Biological process 
Gastrulation  definition   [KW-0306]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 55997
PRO: PR:P0CG37