PGA4 - Pepsin A-4 - human protein (Function)
 
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PGA4 »  Pepsin A-4   [ EC 3.4.23.1 ]
 
Protein also known as:  Pepsinogen-4.
Gene name:  PGA4
Family name: Peptidase A1
Entry whose protein(s) existence is based on evidence at protein level
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1 13 1
GENE REF ISO

Function

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Overview 
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.  
  • CuratedUniProtKB
GO molecular function 
Aspartic-type endopeptidase activitydefinition[GO:0004190]  
  • IEAUniProtKB KW
GO biological process 
Digestiondefinition[GO:0007586]  
  • IEAUniProtKB KW
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.23.1: Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin.  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Digestion  definition   [KW-0222]
Molecular function 
Aspartyl protease  definition   [KW-0064]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 643847
PRO: PR:P0DJD7