SAA1 - Serum amyloid A-1 protein - human protein (Function)
 
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SAA1 »  Serum amyloid A-1 protein  (SAA)
 
Cleaved into:  Amyloid protein A; Serum amyloid protein A(2-102); Serum amyloid protein A(2-103); Serum amyloid protein A(2-104); Serum amyloid protein A(3-104); Serum amyloid protein A(4-101).
Gene name:  SAA1
Family name: SAA
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Major acute phase protein.  
1
  • UniProtKB
GO molecular function 
Chemoattractant activitydefinition[GO:0042056]  
1
  • RefGenome
G-protein coupled receptor bindingdefinition[GO:0001664]  
1
  • UniProtKB
Heparin bindingdefinition[GO:0008201]  
1
  • UniProtKB KW
GO biological process 
Activation of MAPK activitydefinition[GO:0000187] silver  
1
  • CACAO
Acute-phase responsedefinition[GO:0006953]  
1
  • UniProtKB
Lymphocyte chemotaxisdefinition[GO:0048247]  
1
  • UniProtKB
Macrophage chemotaxisdefinition[GO:0048246]  
1
  • UniProtKB
Negative regulation of inflammatory responsedefinition[GO:0050728]  
1
  • UniProtKB
Neutrophil chemotaxisdefinition[GO:0030593]  
1
  • UniProtKB
Platelet activationdefinition[GO:0030168]  
1
  • UniProtKB
Positive chemotaxisdefinition[GO:0050918]  
1
  • RefGenome
Positive regulation of cell adhesiondefinition[GO:0045785]  
3
  • UniProtKB
Positive regulation of cytokine secretiondefinition[GO:0050715]  
1
  • UniProtKB
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
2
  • UniProtKB
Positive regulation of interleukin-1 secretiondefinition[GO:0050716]  
1
  • UniProtKB
Regulation of protein secretiondefinition[GO:0050708]  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Advanced glycosylation endproduct receptor signaling  R-HSA-879415  
Amyloids  R-HSA-977225  
DEx/H-box helicases activate type I IFN and inflammatory cytokines production  R-HSA-3134963  
Formyl peptide receptors bind formyl peptides and many other ligands  R-HSA-444473  
G alpha (i) signalling events  R-HSA-418594  
G alpha (q) signalling events  R-HSA-416476  
RIP-mediated NFkB activation via ZBP1  R-HSA-1810476  
Scavenging by Class B Receptors  R-HSA-3000471  
TAK1 activates NFkB by phosphorylation and activation of IKKs complex  R-HSA-445989  
TRAF6 mediated NF-kB activation  R-HSA-933542  
 

Keywords

Biological process 
Acute phase  definition   [KW-0011]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Serum_amyloid_A1
GenomeRNAi: 6288
PRO: PR:P0DJI8