GZMB - Granzyme B - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
GZMB »  Granzyme B
 
Gene name:  GZMB
Family name: Peptidase S1 » Granzyme
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 179 1
GENE REF ISO

Function

 show evidences
Overview 
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIIntAct
Serine-type endopeptidase activitydefinition[GO:0004252]  
2
  • TASUniProtKB
Serine-type peptidase activitydefinition[GO:0008236]  
1
  • TASPINC
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • TASUniProtKB
Cytolysisdefinition[GO:0019835]  
  • IEAUniProtKB KW
Granzyme-mediated apoptotic signaling pathwaydefinition[GO:0008626] silver  
  • IBARefGenome
Proteolysisdefinition[GO:0006508] silver  
  • IBARefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.79: Preferential cleavage: -Asp-|-Xaa- >> -Asn-|-Xaa- > -Met-|-Xaa-, -Ser-|-Xaa-.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Inactivated by the serine protease inhibitor diisopropylfluorophosphate.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Allograft rejection  hsa05330+3002  
Autoimmune thyroid disease  hsa05320+3002  
Graft-versus-host disease  hsa05332+3002  
Natural killer cell mediated cytotoxicity  hsa04650+3002  
Type I diabetes mellitus  hsa04940+3002  
According to Reactome, this protein belongs to the following pathways:
Activation, myristolyation of BID and translocation to mitochondria  REACT_701  
NOTCH2 intracellular domain regulates transcription  REACT_163910  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Cytolysis  definition   [KW-0204]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GZMB
GenomeRNAi: 3002
PRO: PR:P10144