IL8 - Interleukin-8 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
IL8 »  Interleukin-8  (IL-8)
 
Protein also known as:  Monocyte-derived neutrophil-activating peptide (MONAP). Cleaved into:  IL-8(5-77); IL-8(6-77); IL-8(7-77); IL-8(8-77); IL-8(9-77); Interleukin-8; MDNCF-a.
Gene name:  IL8
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 1212 2
GENE REF ISO

Function

 show evidences
Overview 
IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.  
3
  • CuratedUniProtKB
GO molecular function 
Chemokine activitydefinition[GO:0008009]  
1
  • TASUniProtKB
Interleukin-8 receptor bindingdefinition[GO:0005153]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • TASUniProtKB
Calcium-mediated signalingdefinition[GO:0019722]  
1
  • TASUniProtKB
Cell cycle arrestdefinition[GO:0007050]  
1
  • IDAUniProtKB
Cellular component movementdefinition[GO:0006928]  
1
  • TASPINC
Cellular response to fibroblast growth factor stimulusdefinition[GO:0044344]  
1
  • IEPUniProtKB
Cellular response to interleukin-1definition[GO:0071347]  
1
  • IEPUniProtKB
Cellular response to lipopolysaccharidedefinition[GO:0071222]  
1
  • IDABHF-UCL
Cellular response to tumor necrosis factordefinition[GO:0071356]  
1
  • IEPUniProtKB
Chemotaxisdefinition[GO:0006935]  
1
  • TASUniProtKB
Embryonic digestive tract developmentdefinition[GO:0048566]  
1
  • IEPDFLAT
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Immune responsedefinition[GO:0006955] silver  
  • IEAInterPro 2 GO
Induction of positive chemotaxisdefinition[GO:0050930]  
1
  • IGIUniProtKB
Inflammatory responsedefinition[GO:0006954]  
1
  • TASUniProtKB
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IDAUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • TASPINC
Negative regulation of G-protein coupled receptor protein signaling pathwaydefinition[GO:0045744]  
1
  • IDAUniProtKB
Neutrophil activationdefinition[GO:0042119]  
1
  • TASUniProtKB
Neutrophil chemotaxisdefinition[GO:0030593]  
1
  • IGIUniProtKB
Positive regulation of neutrophil chemotaxisdefinition[GO:0090023]  
1
  • TASBHF-UCL
Receptor internalizationdefinition[GO:0031623]  
1
  • IDAUniProtKB
Regulation of cell adhesiondefinition[GO:0030155]  
1
  • IDAUniProtKB
Regulation of single stranded viral RNA replication via double stranded DNA intermediatedefinition[GO:0045091]  
1
  • IDAUniProtKB
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
1
  • IDAUniProtKB
Response to molecule of bacterial origindefinition[GO:0002237]  
1
  • IDABHF-UCL
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+3576  
Bladder cancer  hsa05219+3576  
Chagas disease (American trypanosomiasis)  hsa05142+3576  
Chemokine signaling pathway  hsa04062+3576  
Cytokine-cytokine receptor interaction  hsa04060+3576  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+3576  
Hepatitis C  hsa05160+3576  
Influenza A  hsa05164+3576  
Legionellosis  hsa05134+3576  
Malaria  hsa05144+3576  
NOD-like receptor signaling pathway  hsa04621+3576  
Pathways in cancer  hsa05200+3576  
Pertussis  hsa05133+3576  
Rheumatoid arthritis  hsa05323+3576  
RIG-I-like receptor signaling pathway  hsa04622+3576  
Salmonella infection  hsa05132+3576  
Shigellosis  hsa05131+3576  
Toll-like receptor signaling pathway  hsa04620+3576  
According to Reactome, this protein belongs to the following pathways:
Cellular responses to stress  REACT_120956  
Metabolism of proteins  REACT_17015  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Chemotaxis  definition   [KW-0145]
Inflammatory response  definition   [KW-0395]
Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Interleukin_8
GenomeRNAi: 3576
PRO: PR:P10145