MYB - Transcriptional activator Myb - human protein (Function)
 
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Protein
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MYB »  Transcriptional activator Myb
 
Protein also known as:  Proto-oncogene c-Myb.
Gene name:  MYB
Entry whose protein(s) existence is based on evidence at protein level
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1 143 12
GENE REF ISO

Function

 show evidences
Overview 
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.  
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAInterPro 2 GO
DNA bindingdefinition[GO:0003677] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
GO biological process 
B cell differentiationdefinition[GO:0030183] silver  
  • IEAOrtholog Compara
Calcium ion transportdefinition[GO:0006816] silver  
  • IEAOrtholog Compara
Chromatin remodelingdefinition[GO:0006338]  
1
  • IMPUniProtKB
Embryonic digestive tract developmentdefinition[GO:0048566] silver  
  • IEAOrtholog Compara
G1/S transition of mitotic cell cycledefinition[GO:0000082] silver  
  • IEAOrtholog Compara
Homeostasis of number of cellsdefinition[GO:0048872] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IMPBHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IMPBHF-UCL
Positive regulation of histone H3-K4 methylationdefinition[GO:0051571]  
1
  • IMPUniProtKB
Positive regulation of histone H3-K9 methylationdefinition[GO:0051574]  
1
  • IMPUniProtKB
Positive regulation of T-helper cell differentiationdefinition[GO:0045624]  
1
  • IMPUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IDAUniProtKB
  • IMPBHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
3
  • IMPUniProtKB
  • IMPBHF-UCL
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • NASUniProtKB
Thymus developmentdefinition[GO:0048538] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
HTLV-I infection  hsa05166+4602  
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MYB_(gene)
GenomeRNAi: 4602
PRO: PR:P10242