AR - Androgen receptor - human protein (Function)
 
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AR »  Androgen receptor
 
Protein also known as:  Nuclear receptor subfamily 3 group C member 4.
Gene name:  AR
Family name: Nuclear hormone receptor » NR3
Entry whose protein(s) existence is based on evidence at protein level
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1 1068 2
GENE REF ISO

Function

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Overview 
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.  
7
  • CuratedUniProtKB
GO molecular function 
Androgen bindingdefinition[GO:0005497]  
1
  • NASUniProtKB
Androgen receptor activitydefinition[GO:0004882]  
6
  • IDAUniProtKB
  • IDABHF-UCL
Androgen receptor bindingdefinition[GO:0050681] silver  
  • IEAOrtholog Compara
Beta-catenin bindingdefinition[GO:0008013]  
3
  • TASAgBase
  • IDABHF-UCL
Chromatin bindingdefinition[GO:0003682]  
1
  • IDAUniProtKB
DNA bindingdefinition[GO:0003677]  
1
  • NASUniProtKB
Enzyme bindingdefinition[GO:0019899]  
2
  • IPIUniProtKB
  • IPIBHF-UCL
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879]  
1
  • IDABHF-UCL
POU domain bindingdefinition[GO:0070974] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
39
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein dimerization activitydefinition[GO:0046983]  
1
  • NASUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
RNA polymerase II transcription factor bindingdefinition[GO:0001085]  
1
  • IPIBHF-UCL
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • IDAUniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIBHF-UCL
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
3
  • IDAUniProtKB
  • IDABHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Activation of prostate induction by androgen receptor signaling pathwaydefinition[GO:0060520] silver  
  • IEAOrtholog Compara
Androgen receptor signaling pathwaydefinition[GO:0030521]  
2
  • IDAUniProtKB
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Cell growthdefinition[GO:0016049]  
1
  • NASUniProtKB
Cell proliferationdefinition[GO:0008283]  
1
  • NASUniProtKB
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Epithelial cell differentiation involved in prostate gland developmentdefinition[GO:0060742] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
1
  • IDABHF-UCL
Lateral sprouting involved in mammary gland duct morphogenesisdefinition[GO:0060599] silver  
  • IEAOrtholog Compara
Male genitalia morphogenesisdefinition[GO:0048808] silver  
  • IEAOrtholog Compara
Male gonad developmentdefinition[GO:0008584] silver  
  • IEAOrtholog Compara
Male somatic sex determinationdefinition[GO:0019102] silver  
  • IEAOrtholog Compara
Mammary gland alveolus developmentdefinition[GO:0060749] silver  
  • IEAOrtholog Compara
Morphogenesis of an epithelial folddefinition[GO:0060571] silver  
  • IEAOrtholog Compara
Negative regulation of epithelial cell proliferationdefinition[GO:0050680] silver  
  • IEAOrtholog Compara
Negative regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001237]  
1
  • IDABHF-UCL
Negative regulation of integrin biosynthetic processdefinition[GO:0045720]  
1
  • IDABHF-UCL
Organ formationdefinition[GO:0048645] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IDABHF-UCL
Positive regulation of insulin-like growth factor receptor signaling pathwaydefinition[GO:0043568] silver  
  • IEAOrtholog Compara
Positive regulation of integrin biosynthetic processdefinition[GO:0045726]  
1
  • IDABHF-UCL
Positive regulation of intracellular estrogen receptor signaling pathwaydefinition[GO:0033148] silver  
  • IEAOrtholog Compara
Positive regulation of MAPK cascadedefinition[GO:0043410] silver  
  • IEAOrtholog Compara
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IMPBHF-UCL
Positive regulation of phosphorylationdefinition[GO:0042327]  
1
  • IMPBHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
4
  • IDAUniProtKB
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase III promoterdefinition[GO:0045945]  
1
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Prostate gland developmentdefinition[GO:0030850]  
1
  • NASUniProtKB
Prostate gland epithelium morphogenesisdefinition[GO:0060740] silver  
  • IEAOrtholog Compara
Prostate gland growthdefinition[GO:0060736] silver  
  • IEAOrtholog Compara
Protein oligomerizationdefinition[GO:0051259]  
1
  • IDAMGI
Regulation of catalytic activitydefinition[GO:0050790] silver  
  • IEAOrtholog Compara
Regulation of developmental growthdefinition[GO:0048638] silver  
  • IEAOrtholog Compara
Regulation of establishment of protein localization to plasma membranedefinition[GO:0090003]  
1
  • IDABHF-UCL
Regulation of prostatic bud formationdefinition[GO:0060685] silver  
  • IEAOrtholog Compara
Regulation of systemic arterial blood pressuredefinition[GO:0003073] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868] silver  
  • IEAOrtholog Compara
Sex differentiationdefinition[GO:0007548]  
1
  • NASUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Tertiary branching involved in mammary gland duct morphogenesisdefinition[GO:0060748] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • IDAUniProtKB
Transportdefinition[GO:0006810]  
1
  • TASPINC
Enzymatic activity 
It is regulated in the following manner
AIM-100 (4-amino-5,6-biaryl-furo[2,3-d]pyrimidine) suppresses TNK2-mediated phosphorylation at Tyr-267. Inhibits the binding of the Tyr-267 phosphorylated form to androgen-responsive enhancers (AREs) and its transcriptional activity.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Oocyte meiosis  hsa04114+367  
Pathways in cancer  hsa05200+367  
Prostate cancer  hsa05215+367  
According to Reactome, this protein belongs to the following pathway:
Gene Expression  REACT_71  
Note 
The level of tyrosine phosphorylation may serve as a diagnostic tool to predict patient outcome in response to hormone-ablation therapy. Inhibition of tyrosine phosphorylation may be an effective intervention target for hormone-refractory prostate cancer.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Androgen_receptor
GenomeRNAi: 367
PRO: PR:P10275
Chemistry
GuidetoPHARMACOLOGY: 628