RARA - Retinoic acid receptor alpha - human protein (Function)
 
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RARA »  Retinoic acid receptor alpha  (RAR-alpha)
 
Protein also known as:  Nuclear receptor subfamily 1 group B member 1.
Gene name:  RARA
Family name: Nuclear hormone receptor » NR1
Entry whose protein(s) existence is based on evidence at protein level
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1 84 3
GENE REF ISO

Function

 show evidences
Overview 
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.  
5
  • UniProtKB
GO molecular function 
Alpha-actinin bindingdefinition[GO:0051393]  
1
  • UniProtKB
Chromatin DNA bindingdefinition[GO:0031490]  
1
  • UniProtKB
Drug bindingdefinition[GO:0008144] silver  
1
  • Ortholog Compara
Enzyme bindingdefinition[GO:0019899]  
2
  • UniProtKB
mRNA 5'-UTR bindingdefinition[GO:0048027] silver  
1
  • Ortholog Compara
Phosphatidylinositol 3-kinase regulator activitydefinition[GO:0035014] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
22
  • IntAct
  • UniProtKB
  • BHF-UCL
Protein domain specific bindingdefinition[GO:0019904]  
1
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • UniProtKB
Protein kinase A bindingdefinition[GO:0051018]  
1
  • UniProtKB
Protein kinase B bindingdefinition[GO:0043422]  
1
  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • UniProtKB
Retinoic acid bindingdefinition[GO:0001972]  
1
  • BHF-UCL
Retinoic acid receptor activitydefinition[GO:0003708]  
1
  • BHF-UCL
Retinoic acid-responsive element bindingdefinition[GO:0044323]  
1
  • UniProtKB
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977] silver  
1
  • Ortholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • UniProtKB
Steroid hormone receptor activitydefinition[GO:0003707] silver  
1
  • InterPro 2 GO
Transcription coactivator activitydefinition[GO:0003713]  
3
  • UniProtKB
  • BHF-UCL
Transcription corepressor activitydefinition[GO:0003714]  
1
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • UniProtKB
Translation repressor activity, nucleic acid bindingdefinition[GO:0000900] silver  
1
  • Ortholog Compara
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Apoptotic cell clearancedefinition[GO:0043277]  
1
  • UniProtKB
Cellular response to estrogen stimulusdefinition[GO:0071391]  
1
  • UniProtKB
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
1
  • Ortholog Compara
Cellular response to retinoic aciddefinition[GO:0071300]  
1
  • UniProtKB
Chondroblast differentiationdefinition[GO:0060591] silver  
1
  • Ortholog Compara
Embryonic camera-type eye developmentdefinition[GO:0031076] silver  
1
  • Ortholog Compara
Face developmentdefinition[GO:0060324] silver  
1
  • Ortholog Compara
Female pregnancydefinition[GO:0007565] silver  
1
  • Ortholog Compara
Germ cell developmentdefinition[GO:0007281] silver  
1
  • Ortholog Compara
Glandular epithelial cell developmentdefinition[GO:0002068] silver  
1
  • Ortholog Compara
Growth plate cartilage developmentdefinition[GO:0003417] silver  
1
  • Ortholog Compara
Intracellular estrogen receptor signaling pathwaydefinition[GO:0030520]  
1
  • BHF-UCL
Limb developmentdefinition[GO:0060173] silver  
1
  • Ortholog Compara
Liver developmentdefinition[GO:0001889] silver  
1
  • Ortholog Compara
Multicellular organism growthdefinition[GO:0035264] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
1
  • Ortholog Compara
Negative regulation of cartilage developmentdefinition[GO:0061037] silver  
1
  • Ortholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
1
  • Ortholog Compara
Negative regulation of granulocyte differentiationdefinition[GO:0030853]  
1
  • UniProtKB
Negative regulation of interferon-gamma productiondefinition[GO:0032689]  
1
  • BHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • UniProtKB
Negative regulation of translational initiationdefinition[GO:0045947] silver  
1
  • Ortholog Compara
Negative regulation of tumor necrosis factor productiondefinition[GO:0032720]  
1
  • BHF-UCL
Neural tube closuredefinition[GO:0001843] silver  
1
  • Ortholog Compara
Outflow tract septum morphogenesisdefinition[GO:0003148] silver  
1
  • Ortholog Compara
Positive regulation of bindingdefinition[GO:0051099]  
1
  • UniProtKB
Positive regulation of cell cycledefinition[GO:0045787]  
1
  • UniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • UniProtKB
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374] silver  
1
  • Ortholog Compara
Positive regulation of interleukin-13 productiondefinition[GO:0032736]  
1
  • BHF-UCL
Positive regulation of interleukin-4 productiondefinition[GO:0032753]  
1
  • BHF-UCL
Positive regulation of interleukin-5 productiondefinition[GO:0032754]  
1
  • BHF-UCL
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
1
  • Ortholog Compara
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068] silver  
1
  • Ortholog Compara
Positive regulation of protein kinase B signalingdefinition[GO:0051897] silver  
1
  • Ortholog Compara
Positive regulation of T-helper 2 cell differentiationdefinition[GO:0045630]  
1
  • BHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • UniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
4
  • UniProtKB
Prostate gland developmentdefinition[GO:0030850] silver  
1
  • Ortholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • UniProtKB
Regulation of myelinationdefinition[GO:0031641] silver  
1
  • Ortholog Compara
Regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043551] silver  
1
  • Ortholog Compara
Regulation of synaptic plasticitydefinition[GO:0048167] silver  
1
  • Ortholog Compara
Response to cytokinedefinition[GO:0034097] silver  
1
  • Ortholog Compara
Response to estradioldefinition[GO:0032355]  
1
  • BHF-UCL
Response to ethanoldefinition[GO:0045471] silver  
1
  • Ortholog Compara
Response to retinoic aciddefinition[GO:0032526]  
1
  • BHF-UCL
Response to vitamin Adefinition[GO:0033189] silver  
1
  • Ortholog Compara
Retinoic acid receptor signaling pathwaydefinition[GO:0048384]  
1
  • BHF-UCL
Sertoli cell fate commitmentdefinition[GO:0060010] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • BHF-UCL
Spermatogenesisdefinition[GO:0007283] silver  
1
  • Ortholog Compara
Steroid hormone mediated signaling pathwaydefinition[GO:0043401] silver  
1
  • InterPro 2 GO
Trachea cartilage developmentdefinition[GO:0060534] silver  
1
  • Ortholog Compara
Ureteric bud developmentdefinition[GO:0001657] silver  
1
  • Ortholog Compara
Ventricular cardiac muscle cell differentiationdefinition[GO:0055012] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+5914  
Pathways in cancer  hsa05200+5914  
According to Reactome, this protein belongs to the following pathways:
Nuclear Receptor transcription pathway  REACT_15525  
Orphan transporters  REACT_268444  
Signaling by Retinoic Acid  REACT_267785  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Retinoic_acid_receptor_alpha
GenomeRNAi: 5914
PRO: PR:P10276
Chemistry
GuidetoPHARMACOLOGY: 590