RARA - Retinoic acid receptor alpha - human protein (Function)
 
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RARA »  Retinoic acid receptor alpha  (RAR-alpha)
 
Protein also known as:  Nuclear receptor subfamily 1 group B member 1.
Gene name:  RARA
Family name: Nuclear hormone receptor » NR1
Entry whose protein(s) existence is based on evidence at protein level
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1 65 3
GENE REF ISO

Function

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Overview 
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.  
4
  • CuratedUniProtKB
GO molecular function 
Chromatin DNA bindingdefinition[GO:0031490]  
1
  • IDAUniProtKB
Drug bindingdefinition[GO:0008144] silver  
  • IEAOrtholog Compara
Enzyme bindingdefinition[GO:0019899]  
2
  • IPIUniProtKB
mRNA 5'-UTR bindingdefinition[GO:0048027] silver  
  • IEAOrtholog Compara
Phosphatidylinositol 3-kinase regulator activitydefinition[GO:0035014] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
17
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein domain specific bindingdefinition[GO:0019904]  
1
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IDAUniProtKB
Protein kinase A bindingdefinition[GO:0051018]  
1
  • IDAUniProtKB
Protein kinase B bindingdefinition[GO:0043422]  
1
  • IPIUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • IDAUniProtKB
Retinoic acid bindingdefinition[GO:0001972]  
1
  • IDABHF-UCL
Retinoic acid receptor activitydefinition[GO:0003708]  
1
  • IDABHF-UCL
Retinoic acid-responsive element bindingdefinition[GO:0044323]  
1
  • IDAUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • IDAUniProtKB
Steroid hormone receptor activitydefinition[GO:0003707] silver  
  • IEAInterPro 2 GO
Transcription coactivator activitydefinition[GO:0003713]  
3
  • IMPUniProtKB
  • IDABHF-UCL
Transcription corepressor activitydefinition[GO:0003714]  
1
  • IDAUniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIUniProtKB
Translation repressor activity, nucleic acid bindingdefinition[GO:0000900] silver  
  • IEAOrtholog Compara
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Apoptotic cell clearancedefinition[GO:0043277]  
1
  • IMPUniProtKB
Cellular response to estrogen stimulusdefinition[GO:0071391]  
1
  • IDAUniProtKB
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
  • IEAOrtholog Compara
Cellular response to retinoic aciddefinition[GO:0071300]  
1
  • IDAUniProtKB
Chondroblast differentiationdefinition[GO:0060591] silver  
  • IEAOrtholog Compara
Female pregnancydefinition[GO:0007565] silver  
  • IEAOrtholog Compara
Germ cell developmentdefinition[GO:0007281] silver  
  • IEAOrtholog Compara
Growth plate cartilage developmentdefinition[GO:0003417] silver  
  • IEAOrtholog Compara
Intracellular estrogen receptor signaling pathwaydefinition[GO:0030520]  
1
  • IDABHF-UCL
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Multicellular organism growthdefinition[GO:0035264] silver  
  • IEAOrtholog Compara
Negative regulation of cartilage developmentdefinition[GO:0061037] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of granulocyte differentiationdefinition[GO:0030853]  
1
  • IDAUniProtKB
Negative regulation of interferon-gamma productiondefinition[GO:0032689]  
1
  • IDABHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Negative regulation of translational initiationdefinition[GO:0045947] silver  
  • IEAOrtholog Compara
Negative regulation of tumor necrosis factor productiondefinition[GO:0032720]  
1
  • IDABHF-UCL
Positive regulation of bindingdefinition[GO:0051099]  
1
  • IMPUniProtKB
Positive regulation of cell cycledefinition[GO:0045787]  
1
  • IMPUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IMPUniProtKB
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-13 productiondefinition[GO:0032736]  
1
  • IDABHF-UCL
Positive regulation of interleukin-4 productiondefinition[GO:0032753]  
1
  • IDABHF-UCL
Positive regulation of interleukin-5 productiondefinition[GO:0032754]  
1
  • IDABHF-UCL
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
  • IEAOrtholog Compara
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068] silver  
  • IEAOrtholog Compara
Positive regulation of protein kinase B signalingdefinition[GO:0051897] silver  
  • IEAOrtholog Compara
Positive regulation of T-helper 2 cell differentiationdefinition[GO:0045630]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IMPUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
4
  • IDAUniProtKB
Prostate gland developmentdefinition[GO:0030850] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • IMPUniProtKB
Regulation of apoptotic processdefinition[GO:0042981] silver  
  • IEAOrtholog Compara
Regulation of myelinationdefinition[GO:0031641] silver  
  • IEAOrtholog Compara
Regulation of synaptic plasticitydefinition[GO:0048167] silver  
  • IEAOrtholog Compara
Response to cytokinedefinition[GO:0034097] silver  
  • IEAOrtholog Compara
Response to estradioldefinition[GO:0032355]  
1
  • IDABHF-UCL
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to retinoic aciddefinition[GO:0032526]  
1
  • IMPBHF-UCL
Response to vitamin Adefinition[GO:0033189] silver  
  • IEAOrtholog Compara
Retinoic acid receptor signaling pathwaydefinition[GO:0048384]  
1
  • IMPBHF-UCL
Sertoli cell fate commitmentdefinition[GO:0060010] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • IDABHF-UCL
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Ureteric bud developmentdefinition[GO:0001657] silver  
  • IEAOrtholog Compara
Ventricular cardiac muscle cell differentiationdefinition[GO:0055012] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+5914  
Pathways in cancer  hsa05200+5914  
According to Reactome, this protein belongs to the following pathway:
Gene Expression  REACT_71  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Retinoic_acid_receptor_alpha
GenomeRNAi: 5914
PRO: PR:P10276
Chemistry
GuidetoPHARMACOLOGY: 590