ACR - Acrosin - human protein (Function)
 
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Protein
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ACR »  Acrosin   [ EC 3.4.21.10 ]
 
Cleaved into:  Acrosin heavy chain; Acrosin light chain.
Gene name:  ACR
Family name: Peptidase S1
Entry whose protein(s) existence is based on evidence at transcript level
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1 25 1
GENE REF ISO

Function

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Overview 
Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.  
  • CuratedUniProtKB
GO molecular function 
Amidase activitydefinition[GO:0004040]  
  • ISSOrtholog Curator
Copper ion bindingdefinition[GO:0005507]  
1
  • NASUniProtKB
DNA bindingdefinition[GO:0003677]  
1
  • NASUniProtKB
Drug bindingdefinition[GO:0008144]  
  • ISSOrtholog Curator
Fucose bindingdefinition[GO:0042806]  
  • ISSOrtholog Curator
Mannose bindingdefinition[GO:0005537]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
Serine-type endopeptidase activitydefinition[GO:0004252]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • NASUniProtKB
GO biological process 
Acrosome matrix dispersaldefinition[GO:0002077]  
1
  • NASUniProtKB
Acrosome reactiondefinition[GO:0007340]  
1
  • IMPUniProtKB
Activation of adenylate cyclase activitydefinition[GO:0007190]  
1
  • IDAUniProtKB
Binding of sperm to zona pellucidadefinition[GO:0007339] silver  
  • IEAOrtholog Compara
Not  Penetration of zona pellucidadefinition[GO:0007341]  
1
  • IDAUniProtKB
Response to steroid hormonedefinition[GO:0048545] silver  
  • IEAOrtholog Compara
Single fertilizationdefinition[GO:0007338]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.10: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by SERPINA5.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Reproduction  REACT_163848  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Acrosin
GenomeRNAi: 49
PRO: PR:P10323